HuLPr03788

Uniprot ID

ACV1C_HUMAN

Uniprot Acc

Q8NER5;Q4ZFZ8;Q86UL1;Q86UL2;Q8TBG2;

Protein name

Activin receptor type-1C

Comment

FUNCTION:Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.||CATALYTIC ACTIVITY:ATP + [receptor-protein] = ADP + [receptor- protein] phosphate.||COFACTOR:Magnesium or manganese.||SUBUNIT:Binds the type 2 receptor protein ACVR2A (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NER5-1; Sequence=Displayed; Name=2; Synonyms=B, soluble B; IsoId=Q8NER5-2; Sequence=VSP 051841; Name=3; Synonyms=A, soluble A; IsoId=Q8NER5-3; Sequence=VSP 051842; Name=4; Synonyms=Truncated;

Subcellular localization

Membrane;Single-pass type I membrane protein.

Gene name

activin A receptor, type IC

Protein sequence

MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTC QTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSN NVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIII TVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSE CNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIV LQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFRE AEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHE QGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGT QGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSIL NTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADI YSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEE MRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANG AARLTALRIKKTISQLCVKEDCKA

Database cross reference

RefSeq Protein accession:NP_001104501
RefSeq Protein gi:161333835

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0048179;C:activin receptor complex;IDA:UniProtKB.

GO-F

GO:0016361;F:activin receptor activity, type I;IDA:UniProtKB. GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0046872;F:metal ion binding;IC:UniProtKB. GO:0005024;F:transforming growth factor beta receptor activity;IEA:InterPro.

GO-P

GO:0006915;P:apoptosis;IEA:UniProtKB-KW. GO:0030154;P:cell differentiation;IDA:UniProtKB. GO:0006468;P:protein phosphorylation;IC:UniProtKB. GO:0042981;P:regulation of apoptosis;IDA:UniProtKB.

TGF-