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Protein basic information

LiverAtlas Protein ID

HuLPr03793

Uniprot ID

ACY3_HUMAN

Uniprot Acc

Q96HD9;

Protein name

Aspartoacylase-2

Comment

FUNCTION:Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity).||COFACTOR:Binds 1 zinc ion per subunit (Potential).||SUBUNIT:Homotetramer (By similarity). Interacts with HCV core protein.||SUBCELLULAR LOCATION:Apical cell membrane; Peripheral membrane protein. Cytoplasm. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.||SIMILARITY:Belongs to the AspA/AstE family. Aspartoacylase subfamily.

Subcellular localization

Apical cell membrane;Peripheral membrane protein.Cytoplasm.

Gene name

aspartoacylase (aminocyclase) 3

Protein sequence

MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAE LQRASFSAVPVLANPAATSGCRRYVDHDLNRTFTSSFLN SRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNT TANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLY QRSGEESYNLDSVAKNGLGLELGPQPQGVLRADIFSRMR TLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTE AGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEG ESTVYPVFINEAAYYEKGVAFVQTEKFTFTVPAMPALTPAPSPAS

Database cross reference

RefSeq Protein accession:NP_542389
RefSeq Protein gi:18087825

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0016324;C:apical plasma membrane;IEA:UniProtKB-SubCell. GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell.

GO-F

GO:0016788;F:hydrolase activity, acting on ester bonds;IEA:InterPro. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW.

GO-P

GO:0044419;P:interspecies interaction between organisms;IEA:UniProtKB-KW.