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Protein basic information

LiverAtlas Protein ID

HuLPr03816

Uniprot ID

ADA30_HUMAN

Uniprot Acc

Q9UKF2;A8K8W8;Q5T3X6;Q9UKF1;

Protein name

Disintegrin and metalloproteinase domain-containing protein 30

Comment

FUNCTION:May be involved in spermatogenesis and fertilization.||COFACTOR:Binds 1 zinc ion per subunit (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=Alpha; IsoId=Q9UKF2-1; Sequence=Displayed; Name=Beta; IsoId=Q9UKF2-2; Sequence=VSP 005494;||TISSUE SPECIFICITY:Expressed specifically in testis.||DOMAIN:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.||SIMILARITY:Contains 1 disintegrin domain.||SIMILARITY:Contains 1 EGF-like domain.||SIMILARITY:Contains 1 peptidase M12B domain.

Subcellular localization

Membrane;Single-pass type I membrane protein.

Gene name

ADAM metallopeptidase domain 30

Protein sequence

MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDS YEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWP KRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKE SLDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEH VVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRDFP GSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTG IMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLG RFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSFGKVC SLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQY CQCRGRLNCIMGSGRTGFSNCSYISFFKHISSGATCLNN IPGLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQSN CKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEY CDGNSSSCPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQ SIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKC ESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMC WGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVN SSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPFCEEV GYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSV VFVFFRQVIGNHLKPKQEKMPLSKAKTEQEESKTKTVQE ESKTKTGQEESEAKTGQEESKAKTGQEESKANIESKRPKAKSVKKQKK

Database cross reference

RefSeq Protein accession:NP_068566
RefSeq Protein gi:31881770

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Fetal Liver;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;TAS:ProtInc.

GO-F

GO:0004222;F:metalloendopeptidase activity;IEA:InterPro. GO:0008270;F:zinc ion binding;TAS:ProtInc.

GO-P

GO:0006508;P:proteolysis;IEA:InterPro.