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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr03850

Uniprot ID

ADEC1_HUMAN

Uniprot Acc

O15204;

Protein name

ADAM DEC1

Comment

FUNCTION:May play an important role in the control of the immune response and during pregnancy (By similarity).||COFACTOR:Binds 1 zinc ion per subunit (By similarity).||SUBCELLULAR LOCATION:Secreted (By similarity).||TISSUE SPECIFICITY:Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.||INDUCTION:Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated by bacterial lipopolysaccharides (LPS). Up-regulated by 1-alpha,25- dihydroxyvitamin D3 during differentiation of primary monocyte into macrophage.||SIMILARITY:Contains 1 disintegrin domain.||SIMILARITY:Contains 1 peptidase M12B domain.

Subcellular localization

Secreted(By similarity).

Gene name

ADAM-like, decysin 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MLRGISQLPAVATMSWVLLPVLWLIVQTQAIAIKQTPELT LHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQYQ MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKP ENMEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRY QIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQ GPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYN ENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDG DKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGIS FNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSH ELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTS CRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV GEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAPNHTTE

Database cross reference

RefSeq Protein accession:NP_001138743
RefSeq Protein gi:223671930

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;NAS:UniProtKB.

GO-F

GO:0005178;F:integrin binding;NAS:UniProtKB. GO:0004222;F:metalloendopeptidase activity;NAS:UniProtKB. GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0007229;P:integrin-mediated signaling pathway;NAS:UniProtKB. GO:0007162;P:negative regulation of cell adhesion;NAS:UniProtKB. GO:0006508;P:proteolysis;IEA:InterPro.