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Protein basic information

LiverAtlas Protein ID

HuLPr03852

Uniprot ID

ADH1B_HUMAN

Uniprot Acc

P00325;Q13711;Q4ZGI9;Q96KI7;

Protein name

Alcohol dehydrogenase 1B

Comment

CATALYTIC ACTIVITY:An alcohol + NAD(+) = an aldehyde or ketone + NADH.||COFACTOR:Binds 2 zinc ions per subunit.||SUBUNIT:Dimer of identical or non-identical chains of three types; alpha, beta and gamma.||SUBCELLULAR LOCATION:Cytoplasm.||POLYMORPHISM:Three alleles are known:ADH1B*1 (ADH2*1) corresponding to variant beta-1, ADH1B*2 (ADH2*2) corresponding to variant beta-2, ADH1B*3 (ADH2*3) corresponding to variant beta-3. The sequence shown is that of allele ADH1B*1. The ADH1B*2 allele frequency in orientals is approximately 75%, whereas it is less than 5% in most Caucasian populations.||MISCELLANEOUS:There are 7 different ADH's isozymes in human:three belongs to class-I:alpha, beta, and gamma, one to class-II:pi, one to class-III:chi, one to class-IV:ADH7 and one to class- V:ADH6.||SIMILARITY:Belongs to the zinc-containing alcohol dehydrogenase family.||WEB RESOURCE:Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adh1b/";

Subcellular localization

Cytoplasm.

Gene name

alcohol dehydrogenase 1B (class I), beta polypeptide

Related liver disease name

Hepatocellular carcinoma

Alcoholic liver disease

Protein sequence

MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIK MVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGE GVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLG NPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENA VAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTC AVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKE LGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLD TMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGR TWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLP FEKINEGFDLLHSGKSIRTVLTF

Database cross reference

RefSeq Protein accession:NP_000659
RefSeq Protein gi:34577061

Liver relevance

Liver sepcificity

Yes/No

Yes

Evidence

Translational level from literatures

Quality score

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

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GO-C

GO:0005829;C:cytosol;TAS:Reactome.

GO-F

GO:0004024;F:alcohol dehydrogenase activity, zinc-dependent;IDA:UniProtKB. GO:0008270;F:zinc ion binding;IDA:UniProtKB.