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Protein basic information

LiverAtlas Protein ID

HuLPr03854

Uniprot ID

ADH4_HUMAN

Uniprot Acc

P08319;A8K470;B4DIE7;C9J4A9;Q8TCD7;

Protein name

Alcohol dehydrogenase 4

Comment

CATALYTIC ACTIVITY:An alcohol + NAD(+) = an aldehyde or ketone + NADH.||COFACTOR:Binds 2 zinc ions per subunit.||SUBUNIT:Homodimer.||SUBCELLULAR LOCATION:Cytoplasm.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P08319-1; Sequence=Displayed; Name=2; IsoId=P08319-2; Sequence=VSP 036788;||MISCELLANEOUS:There are 7 different ADH's isozymes in human:three belongs to class-I:alpha, beta, and gamma, one to class-II:pi, one to class-III:chi, one to class-IV:ADH7 and one to class- V:ADH6.||SIMILARITY:Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.||WEB RESOURCE:Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adh4/";

Subcellular localization

Cytoplasm.

Gene name

alcohol dehydrogenase 4 (class II), pi polypeptide

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQ IIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIG PGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISN LKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTV VSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVT PGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKF VKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDC AGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEE LIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALV THTLPFDKISEAFDLMNQGKSVRTILIF

Database cross reference

RefSeq Protein accession:NP_000661
RefSeq Protein gi:71565152

Liver relevance

Liver sepcificity

Yes/No

Yes

Evidence

Translational level from literatures

Quality score

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005829;C:cytosol;TAS:Reactome. GO:0015630;C:microtubule cytoskeleton;IDA:HPA.

GO-F

GO:0004024;F:alcohol dehydrogenase activity, zinc-dependent;IDA:UniProtKB. GO:0005503;F:all-trans retinal binding;IDA:UniProtKB. GO:0019115;F:benzaldehyde dehydrogenase activity;IDA:UniProtKB. GO:0051287;F:NAD binding;IDA:UniProtKB. GO:0003960;F:NADPH:

GO-P

GO:0046164;P:alcohol catabolic p Error!!! Error!!!Go back to the login page