HuLPr03870

Uniprot ID

ADPRM_HUMAN

Uniprot Acc

Q3LIE5;A8K9B4;D3DTS4;Q9BVD4;Q9NRU8;

Protein name

Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase

Comment

FUNCTION:Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).||CATALYTIC ACTIVITY:CDP-choline + H(2)O = CMP + phosphocholine.||CATALYTIC ACTIVITY:ADP-ribose + H(2)O = AMP + D-ribose 5- phosphate.||CATALYTIC ACTIVITY:CDP-glycerol + H(2)O = CMP + sn-glycerol 3- phosphate.||COFACTOR:Magnesium (By similarity).||SUBUNIT:Monomer (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3LIE5-1; Sequence=Displayed; Name=2; IsoId=Q3LIE5-3; Sequence=VSP 025092, VSP 025093; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay;||SIMILARITY:Belongs to the ADPRibase-Mn family.||SEQUENCE CAUTION:Sequence=AAF87317.1; T

Gene name

chromosome 17 open reading frame 48

Protein sequence

MDDKPNPEALSDSSERLFSFGVIADVQFADLEDGFNFQGT RRRYYRHSLLHLQGAIEDWNNESSMPCCVLQLGDIIDGY NAQYNASKKSLELVMDMFKRLKVPVHHTWGNHEFYNFSR EYLTHSKLNTKFLEDQIVHHPETMPSEDYYAYHFVPFPK FRFILLDAYDLSVLGVDQSSPKYEQCMKILREHNPNTEL NSPQGLSEPQFVQFNGGFSQEQLNWLNEVLTFSDTNQEK VVIVSHLPIYPDASDNVCLAWNYRDALAVIWSHECVVCF FAGHTHDGGYSEDPFGVYHVNLEGVIETAPDSQAFGTVH VYPDKMMLKGRGRVPDRIMNYKKERAFHC

Database cross reference

RefSeq Protein accession:NP_064618
RefSeq Protein gi:94158594

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO-F

GO:0047631;F:ADP-ribose diphosphatase activity;IEA:EC. GO:0047734;F:CDP-glycerol diphosphatase activity;IEA:EC. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW.