Protein basic information
| LiverAtlas Protein ID |
HuLPr03884 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q8IUX7;Q14113;Q59ER7;Q6ZSC7;Q7KZ79; |
|
Protein name |
Adipocyte enhancer-binding protein 1 |
|
Comment |
FUNCTION:May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By similarity).||SUBUNIT:Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN (By similarity). May interact with calmodulin (By similarity). Binds to DNA in vitro (By similarity).||SUBCELLULAR LOCATION:Isoform 1:Secreted (By similarity).||SUBCELLULAR LOCATION:Isoform 2:Cytoplasm (Probable). Nucleus (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IUX7-1; Sequence=Displayed; Name=2; IsoId=Q8IUX7-2; Sequence=VSP 033467, VSP 033468, VSP 033469; Note=No experimental confirmation available;||TISSUE SPECIFICITY:E |
|
Subcellular localization |
Isoform 1:Secreted(By similarity). |
|
Gene name |
|
|
Protein sequence
|
MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEG FLSELEPEPREDDVEAPPPPEPTPRVRKAQAGGKPGKRP GTAAEVPPEKTKDKGKKGKKDKGPKVPKESLEGSPRPPK KGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKP PKATKKPPSGKRPPILAPSETLEWPLPPPPSPGPEELPQ EGGAPLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDY NDQIEREDYEDFEYIRRQKQPRPPPSRRRRPERVWPEPP EEKAPAPAPEERIEPPVKPLLPPLPPDYGDGYVIPNYDD MDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEE TDKWAVEKGKDHKEPRKGEELEEEWTPTEKVKCPPIGME SHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYD GAWCAEDDARTQWIEVDTRRTTRFTGVITQGRDSSIHDD FVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVL SELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSVAPVYS YYAQNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITR TYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIH GNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHL VPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFP DLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVST EVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQ EQLLAAAMAAARGEDEDEVSEAQETPDHAIFRWLAISFA SAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTIN DFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALL TFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTA SGGDYWRILNPGEYRVTAHAEGYTPSAKTCNVDYDIGAT QCNFILARSNWKRIREIMAMNGNR |
|
Database cross reference |
RefSeq Protein accession:NP_001120
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005615;C:extracellular space;IDA:BHF-UCL. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. |
|
GO-F |
GO:0003677;F:DNA binding;IEA:UniProtKB-KW. GO:0004181;F:metallocarboxypeptidase activity;IEA:InterPro. GO:0003700;F:sequence-specific DNA binding transcription factor activity;TAS:ProtInc. GO:0008270;F:zinc ion binding;IEA:InterPro. |
|
GO-P |
GO:0007155;P:cell adhesion;IEA:InterPro. GO:0007517;P:muscle organ development;TAS:ProtInc. GO:0006508;P:proteolysis;IEA:InterPro. GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0001501;P:skeletal system development;TAS:Pr |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr03884 |
PHOSPHORYLATION |
404 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr03884 |
ACETYLATION |
598 |
K |
PhosphoSitePlus |
HTP |
N |
|
Pathway
| Pathway name |
