Protein basic information
| LiverAtlas Protein ID |
HuLPr03908 |
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Uniprot ID |
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Uniprot Acc |
Q5I7T1;B2RPF4; |
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Protein name |
Putative alpha-1,2-glucosyltransferase ALG10-B |
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Comment |
FUNCTION:Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2.||PATHWAY:Protein modification; protein glycosylation.||SUBUNIT:Interacts with KCNH1 and KCNH2 (By similarity).||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein (By similarity).||TISSUE SPECIFICITY:Highly expressed in heart, placenta, liver, kidney and pancreas. Weakly expressed in lung, skeletal muscle and brain.||POLYMORPHISM:Genetic variations in ALG10B may reduce susceptibility to acquired long QT syndrome.||SIMILARITY:Belongs to the ALG10 glucosyltransferase family.||CAUTION:PubMed:15280551 reports a Val-447 variant, however there is evidence that |
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Subcellular localization |
Cell membrane;Multi-pass membrane protein(By similarity). |
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Gene name |
asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast) |
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Protein sequence
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MAQLEGYCFSAALSCTFLVSCLLFSAFSRALREPYMDEIF HLPQAQRYCEGHFSLSQWDPMITTLPGLYLVSVGVVKPA IWIFAWSEHVVCSIGMLRFVNLLFSVGNFYLLYLLFHKV QPRNKAASSIQRVLSTLTLAVFPTLYFFNFLYYTEAGSM FFTLFAYLMCLYGNHKTSAFLGFCGFMFRQTNIIWAVFC AGNVIAQKLTEAWKTELQKKEDRLPPIKGPFAEFRKILQ FLLAYSMSFKNLSMLFCLTWPYILLGFLFCAFVVVNGGI VIGDRSSHEACLHFPQLFYFFSFTLFFSFPHLLSPSKIK TFLSLVWKHGILFLVVTLVSVFLVWKFTYAHKYLLADNR HYTFYVWKRVFQRYAILKYLLVPAYIFAGWSIADSLKSK PIFWNLMFFICLFIVIVPQKLLEFRYFILPYVIYRLNIT LPPTSRLVCELSCYAIVNFITFYIFLNKTFQWPNSQDIQRFMW |
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Database cross reference |
RefSeq Protein accession:NP_001013642
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005789;C:endoplasmic reticulum membrane;TAS:Reactome. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0004583;F:dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity;TAS:Reactome. |
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GO-P |
GO:0006488;P:dolichol-linked oligosaccharide biosynthetic process;EXP:Reactome. GO:0043687;P:post-translational protein modification;TAS:Reactome. GO:0018279;P:protein N-linked glycosylation via asparagine;TAS:Reactome. |
Pathway
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