Protein basic information
| LiverAtlas Protein ID |
HuLPr03947 |
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Uniprot ID |
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Uniprot Acc |
Q96BJ3;A8K1F0;Q49A81;Q5JRA4;Q658P1;Q9H9E8; |
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Protein name |
Axin interactor, dorsalization-associated protein |
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Comment |
FUNCTION:Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).||SUBUNIT:Interacts with AXIN1 (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96BJ3-1; Sequence=Displayed; Name=2; IsoId=Q96BJ3-2; Sequence=VSP 028322; Note=No experimental confirmation available; Name=3; IsoId=Q96BJ3-3; Sequence=VSP 034661; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle.||SIMILARITY:Belongs to the AIDA family. |
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Gene name |
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Protein sequence
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MSEVTRSLLQRWGASFRRGADFDSWGQLVEAIDEYQILAR HLQKEAQAQHNNSEFTEEQKKTIGKIATCLELRSAALQS TQSQEEFKLEDLKKLEPILKNILTYNKEFPFDVQPVPLR RILAPGEEENLEFEEDEEEGGAGAGSPDSFPARVPGTLL PRLPSEPGMTLLTIRIEKIGLKDAGQCIDPYITVSVKDL NGIDLTPVQDTPVASRKEDTYVHFNVDIELQKHVEKLTK GAAIFFEFKHYKPKKRFTSTKCFAFMEMDEIKPGPIVIE LYKKPTDFKRKKLQLLTKKPLYLHLHQTLHKE |
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Database cross reference |
RefSeq Protein accession:NP_073742
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
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GO-P |
GO:0009953;P:dorsal/ventral pattern formation;ISS:UniProtKB. GO:0046329;P:negative regulation of JNK cascade;ISS:UniProtKB. GO:0043508;P:negative regulation of JUN kinase activity;IDA:MGI. GO:0043496;P:regulation of protein homodimerization activity;ISS |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr03947 |
PHOSPHORYLATION |
144 |
S |
Phospho-ELM |
HTP |
N |
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|
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HuLPr03947 |
ACETYLATION |
235 |
K |
PhosphoSitePlus |
LTP |
N |
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|
|
HuLPr03947 |
PHOSPHORYLATION |
144 |
S |
PhosphoSitePlus |
LTP |
N |
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