HuLPr03951

Uniprot ID

AIFM2_HUMAN

Uniprot Acc

Q9BRQ8;B3KXI0;Q63Z39;

Protein name

Apoptosis-inducing factor 2

Comment

FUNCTION:Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.||COFACTOR:FAD. Binds 6-hydroxy-FAD non-covalently.||SUBCELLULAR LOCATION:Cytoplasm. Mitochondrion outer membrane.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BRQ8-1; Sequence=Displayed; Name=2; IsoId=Q9BRQ8-2; Sequence=VSP 052047, VSP 052048; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major

Subcellular localization

Cytoplasm.Mitochondrion outer membrane.

Gene name

apoptosis-inducing factor, mitochondrion-associated, 2

Protein sequence

MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLV DMKDSFHHNVAALRASVETGFAKKTFISYSVTFKDNFRQ GLVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGK FNEVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEM AAEIKTEYPEKEVTLIHSQVALADKELLPSVRQEVKEIL LRKGVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVA TNLVILCTGIKINSSAYRKAFESRLASSGALRVNEHLQV EGHSNVYAIGDCADVRTPKMAYLAGLHANIAVANIVNSV KQRPLQAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVR LTKSRDLFVSTSWKTMRQSPP

Database cross reference

RefSeq Protein accession:NP_001185625
RefSeq Protein gi:311082415

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005829;C:cytosol;IDA:UniProtKB. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005741;C:mitochondrial outer membrane;IDA:UniProtKB.

GO-F

GO:0003677;F:DNA binding;IDA:UniProtKB. GO:0004174;F:electron-transferring-flavoprotein dehydrogenase activity;IDA:UniProtKB. GO:0050660;F:flavin adenine dinucleotide binding;IDA:UniProtKB.

GO-P

GO:0008637;P:apoptotic mitochondrial changes;NAS:UniProtKB. GO:0030261;P:chromosome condensation;IDA:UniProtKB. GO:0006917;P:induction of apoptosis;IMP:UniProtKB. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr03951

PHOSPHORYLATION

345

Y

PhosphoSitePlus

10943314

LTP

HTP

N

Direct_p53_effectors

TCR