HuLPr04008

Uniprot ID

AL1L1_HUMAN

Uniprot Acc

O75891;Q68CS1;

Protein name

Aldehyde dehydrogenase family 1 member L1

Comment

CATALYTIC ACTIVITY:10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH.||SUBCELLULAR LOCATION:Cytoplasm.||TISSUE SPECIFICITY:Highly expressed in liver, pancreas and kidney.||SIMILARITY:In the N-terminal section; belongs to the GART family.||SIMILARITY:In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.||SIMILARITY:Contains 1 acyl carrier domain.||SEQUENCE CAUTION:Sequence=CAH18667.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Subcellular localization

Cytoplasm.

Gene name

aldehyde dehydrogenase 1 family, member L1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKAD PLGLEAEKDGVPVFKYSRWRAKGQALPDVVAKYQALGAE LNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASA INWTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPD DTVSTLYNRFLFPEGIKGMVQAVRLIAEGKAPRLPQPEE GATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWT EACEQKLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTK AGLILFGNDDKMLLVKNIQLEDGKMILASNFFKGAASSV LELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGA ASVDVVRLVEEVKELCDGLELENEDVYMASTFGDFIQLL VRKLRGDDEEGECSIDYVEMAVNKRTVRMPHQLFIGGEF VDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAK DAFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEA LDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPI NQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAA CLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNV LPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAI SNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNK GENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDR DTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPR PGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDL DAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVF VNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFEY

Database cross reference

RefSeq Protein accession:NP_036322
RefSeq Protein gi:21614513

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO-F

GO:0000036;F:acyl carrier activity;IEA:InterPro. GO:0048037;F:cofactor binding;IEA:InterPro. GO:0016155;F:formyltetrahydrofolate dehydrogenase activity;IEA:EC. GO:0016742;F:hydroxymethyl-, formyl- and related transferase activity;IEA:InterPro. GO:00081

GO-P

GO:0009258;P:10-formyltetrahydrofolate catabolic process;TAS:ProtInc. GO:0009058;P:biosynthetic process;IEA:InterPro. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr04008

ACETYLATION

876

K

PhosphoSitePlus

3842240

LTP

N

HuLPr04008

ACETYLATION

882

K

PhosphoSitePlus

3842246

LTP

N

One_Carbon_Pool_By_Folate