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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr04020

Uniprot ID

AL5AP_HUMAN

Uniprot Acc

P20292;Q5VV04;

Protein name

Arachidonate 5-lipoxygenase-activating protein

Comment

FUNCTION:Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.||SUBUNIT:Homotrimer. Interacts with LTC4S and ALOX5.||SUBCELLULAR LOCATION:Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.||DOMAIN:The C-terminal part after residue 140 is mostly unstructured.||DISEASE:Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneo

Subcellular localization

Nucleus membrane;Multi-pass membrane protein.Endoplasmic reticulum membrane;Multi-pass membrane protein.

Gene name

arachidonate 5-lipoxygenase-activating protein

Protein sequence

MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGR SFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCS QVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRI ILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPL LLIP

Database cross reference

RefSeq Protein accession:NP_001191335
RefSeq Protein gi:324711029

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005792;C:microsome;ISS:RefGenome. GO:0031965;C:nuclear membrane;IDA:UniProtKB.

GO-F

GO:0050544;F:arachidonic acid binding;IDA:UniProtKB. GO:0047485;F:protein N-terminus binding;IPI:UniProtKB.

GO-P

GO:0071277;P:cellular response to calcium ion;IDA:UniProtKB. GO:0019370;P:leukotriene biosynthetic process;IDA:UniProtKB. GO:0002540;P:leukotriene production involved in inflammatory response;ISS:RefGenome. GO:0070207;P:protein homotrimerization;IPI:Uni

Pathway

Pathway name

IL4

Pathway name

Leptin

Pathway name

TGF_beta_Receptor