HuLPr04097

Uniprot ID

AMPO_HUMAN

Uniprot Acc

Q8N6M6;Q5T9B1;Q5T9B3;Q5T9B4;Q8WUL6;Q96M23;Q96SS1;

Protein name

Aminopeptidase O

Comment

FUNCTION:Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.||COFACTOR:Binds 1 zinc ion per subunit (By similarity).||ENZYME REGULATION:Strongly inhibited by ophenanthroline, a metalloprotease inhibitor. Inhibited by arphamenine A, a potent inhibitor of aminopeptidases. Not affected by AEBSF and E-64, which are common inhibitors of serine- and cysteine-proteases, respectively.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=6 uM for Asn-AMC;||SUBCELLULAR LOCATION:Cytoplasm (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8N6M6-1; Sequence=Displayed; Name=2; IsoId=Q8N6M6-2; Sequence=VSP 013161; Name=

Subcellular localization

Cytoplasm(Potential).

Gene name

chromosome 9 open reading frame 3

Protein sequence

MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIE GTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEP CHIPVTNARTFSSEMEYNDFAICSKGEKDTSDKDGNHDN QEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVE EVDVAAVPGLEKFTRSPELTVVSEEFRNQIVRELVTLPA NRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQ TATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVYTVGS PINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENS AKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKME TWSSNDLATERPFSPSEANFRHVGVCSHMEYPCRFQNAS ATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSV LGAHPFSRLDVLIVPANFPSLGMASPHIMFLSQSILTGG NHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHL EDVFWATAQQLAPYEAREQQELRACLRWRRLQDEMQCSP EEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHY LKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQD FLQMLLENIPEEKRLELSVENIYQDWLESSGIPKPLQRE RRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVF EKLLPDQLVLLLEHLLEQKTLSPRTLQSLQRTYHLQDQD AEVRHRWCELIVKHKFTKAYKSVERFLQEDQAMGVYLYG ELMVSEDARQQQLARRCFERTKEQMDRSSAQVVAEMLF

Database cross reference

RefSeq Protein accession:NP_001180258
RefSeq Protein gi:300934738

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell.

GO-F

GO:0004177;F:aminopeptidase activity;IDA:UniProtKB. GO:0008237;F:metallopeptidase activity;IDA:UniProtKB. GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0019370;P:leukotriene biosynthetic process;IEA:InterPro. GO:0006508;P:proteolysis;IDA:UniProtKB.