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Protein basic information

LiverAtlas Protein ID	HuLPr04168
Uniprot ID	ANLN_HUMAN
Uniprot Acc	Q9NQW6;Q5CZ78;Q6NSK5;Q9H8Y4;Q9NVN9;Q9NVP0;
Protein name	Actin-binding protein anillin
Comment	FUNCTION:Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression.\|\|SUBUNIT:Interacts with F-actin. Interacts with CD2AP. May interact with RHOA. Interacts with FZR1/CDH1 during mitotic exit.\|\|INTERACTION:Q8K298:Anln (xeno); NbExp=1; IntAct=EBI-2553589, EBI-2553580;\|\|SUBCELLULAR LOCATION:Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.\|\|ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NQW6-1; Sequence=Displayed; Name=2; IsoId=Q9NQW6-2; Sequence=VSP 017617;\|\|TISSUE SPECIFICITY:Ubiquitously expressed. Present at highest levels in the brain, at high levels
Subcellular localization	Nucleus.Cytoplasm, cytoskeleton.Cytoplasm, cell cortex.
Gene name	anillin, actin binding protein
Protein sequence	MDPFTEKLLERTRARRENLQRKMAERPTAAPRSMTHAKRA RQPLSEASNQQPLSGGEEKSCTKPSPSKKRCSDNTEVEV SNLENKQPVESTSAKSCSPSPVSPQVQPQAADTISDSVA VPASLLGMRRGLNSRLEATAASSVKTRMQKLAEQRRRWD NDDMTDDIPESSLFSPMPSEEKAASPPRPLLSNASATPV GRRGRLANLAATICSWEDDVNHSFAKQNSVQEQPGTACL SKFSSASGASARINSSSVKQEATFCSQRDGDASLNKALS SSADDASLVNASISSSVKATSPVKSTTSITDAKSCEGQN PELLPKTPISPLKTGVSKPIVKSTLSQTVPSKGELSREI CLQSQSKDKSTTPGGTGIKPFLERFGERCQEHSKESPAR STPHRTPIITPNTKAIQERLFKQDTSSSTTHLAQQLKQE RQKELACLRGRFDKGNIWSAEKGGNSKSKQLETKQETHC QSTPLKKHQGVSKTQSLPVTEKVTENQIPAKNSSTEPKG FTECEMTKSSPLKITLFLEEDKSLKVTSDPKVEQKIEVI REIEMSVDDDDINSSKVINDLFSDVLEEGELDMEKSQEE MDQALAESSEEQEDALNISSMSLLAPLAQTVGVVSPESL VSTPRLELKDTSRSDESPKPGKFQRTRVPRAESGDSLGS EDRDLLYSIDAYRSQRFKETERPSIKQVIVRKEDVTSKL DEKNNAFPCQVNIKQKMQELNNEINMQQTVIYQASQALN CCVDEEHGKGSLEEAEAERLLLIATGKRTLLIDELNKLK NEGPQRKNKASPQSEFMPSKGSVTLSEIRLPLKADFVCS TVQKPDAANYYYLIILKAGAENMVATPLASTSNSLNGDA LTFTTTFTLQDVSNDFEINIEVYSLVQKKDPSGLDKKKK TSKSKAITPKRLLTSITTKSNIHSSVMASPGGLSAVRTS NFALVGSYTLSLSSVGNTKFVLDKVPFLSSLEGHIYLKI KCQVNSSVEERGFLTIFEDVSGFG
Database cross reference	RefSeq Protein accession:NP_061155 RefSeq Protein gi:31657094

Liver relevance

HLPP validation	Yes/No	Yes
HLPP validation	Project name	Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C	GO:0005826;C:actomyosin contractile ring;IDA:MGI. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.
GO-F	GO:0003779;F:actin binding;IDA:MGI.
GO-P	GO:0000910;P:cytokinesis;IDA:MGI. GO:0007067;P:mitosis;IEA:UniProtKB-KW. GO:0007096;P:regulation of exit from mitosis;TAS:ProtInc. GO:0000921;P:septin ring assembly;TAS:ProtInc.

Post-translational modification

LiverAtlas Protein ID	MOD type1	Position1	Residue1	Source name1	source ID1	Source method	HLPP validation1 (Yes/no)	Quality score
HuLPr04168	PHOSPHORYLATION	323	S	Phospho-ELM	5428	HTP	N
HuLPr04168	PHOSPHORYLATION	485	S	Phospho-ELM	5429	HTP	N
HuLPr04168	PHOSPHORYLATION	99	S	Phospho-ELM	5427	HTP	N
HuLPr04168	PHOSPHORYLATION	102	S	Phospho-ELM	31077	HTP	N
HuLPr04168	PHOSPHORYLATION	168	S	Phospho-ELM	39345	HTP	N
HuLPr04168	PHOSPHORYLATION	169	S	Phospho-ELM	39346	HTP	N
HuLPr04168	PHOSPHORYLATION	172	S	Phospho-ELM	39347	HTP	N
HuLPr04168	PHOSPHORYLATION	194	T	Phospho-ELM	16865	HTP	N
HuLPr04168	PHOSPHORYLATION	320	T	Phospho-ELM	16866	HTP	N
HuLPr04168	PHOSPHORYLATION	327	T	Phospho-ELM	39360	HTP	N
HuLPr04168	PHOSPHORYLATION	362	S	Phospho-ELM	39348	HTP	N
HuLPr04168	PHOSPHORYLATION	364	T	Phospho-ELM	39361	HTP	N
HuLPr04168	PHOSPHORYLATION	393	T	Phospho-ELM	39362	HTP	N
HuLPr04168	PHOSPHORYLATION	397	T	Phospho-ELM	39363	HTP	N
HuLPr04168	PHOSPHORYLATION	401	T	Phospho-ELM	16867	HTP	N
HuLPr04168	PHOSPHORYLATION	417	S	Phospho-ELM	39349	HTP	N
HuLPr04168	PHOSPHORYLATION	418	S	Phospho-ELM	39350	HTP	N
HuLPr04168	PHOSPHORYLATION	419	S	Phospho-ELM	39351	HTP	N
HuLPr04168	PHOSPHORYLATION	449	S	Phospho-ELM	16868	HTP	N
HuLPr04168	PHOSPHORYLATION	518	S	Phospho-ELM	39352	HTP	N
HuLPr04168	PHOSPHORYLATION	54	S	Phospho-ELM	39342	HTP	N
HuLPr04168	PHOSPHORYLATION	553	S	Phospho-ELM	39353	HTP	N
HuLPr04168	PHOSPHORYLATION	561	S	Phospho-ELM	39354	HTP	N
HuLPr04168	PHOSPHORYLATION	562	S	Phospho-ELM	39355	HTP	N
HuLPr04168	PHOSPHORYLATION	658	S	Phospho-ELM	31078	HTP	N
HuLPr04168	PHOSPHORYLATION	661	S	Phospho-ELM	31079	HTP	N
HuLPr04168	PHOSPHORYLATION	664	S	Phospho-ELM	39356	HTP	N
HuLPr04168	PHOSPHORYLATION	72	S	Phospho-ELM	39343	HTP	N
HuLPr04168	PHOSPHORYLATION	75	T	Phospho-ELM	39359	HTP	N
HuLPr04168	PHOSPHORYLATION	792	S	Phospho-ELM	39357	HTP	N
HuLPr04168	PHOSPHORYLATION	927	S	Phospho-ELM	39358	HTP	N
HuLPr04168	PHOSPHORYLATION	95	S	Phospho-ELM	39344	HTP	N
HuLPr04168	PHOSPHORYLATION	97	S	Phospho-ELM	31076	HTP	N
HuLPr04168	PHOSPHORYLATION	1118	Y	PhosphoSitePlus	2470228	LTP	N
HuLPr04168	PHOSPHORYLATION	416	T	PhosphoSitePlus	18006621	LTP	N
HuLPr04168	PHOSPHORYLATION	295	S	PhosphoSitePlus	4761640	HTP	N
HuLPr04168	PHOSPHORYLATION	642	S	PhosphoSitePlus	4761648	LTP	N
HuLPr04168	PHOSPHORYLATION	792	S	PhosphoSitePlus	4761654	LTP HTP	N
HuLPr04168	ACETYLATION	371	K	PhosphoSitePlus	11323045	LTP	N
HuLPr04168	PHOSPHORYLATION	323	S	PhosphoSitePlus	453248	LTP	N
HuLPr04168	PHOSPHORYLATION	485	S	PhosphoSitePlus	453249	LTP	N
HuLPr04168	PHOSPHORYLATION	99	S	PhosphoSitePlus	453250	LTP	N
HuLPr04168	PHOSPHORYLATION	363	T	PhosphoSitePlus	7322836	LTP	N
HuLPr04168	PHOSPHORYLATION	795	S	PhosphoSitePlus	7322838	LTP	N
HuLPr04168	PHOSPHORYLATION	102	S	PhosphoSitePlus	3213456	LTP	N
HuLPr04168	PHOSPHORYLATION	172	S	PhosphoSitePlus	3213465	LTP	N
HuLPr04168	PHOSPHORYLATION	418	S	PhosphoSitePlus	3213474	LTP HTP	N
HuLPr04168	PHOSPHORYLATION	518	S	PhosphoSitePlus	3213480	LTP	N
HuLPr04168	PHOSPHORYLATION	553	S	PhosphoSitePlus	3213483	LTP	N
HuLPr04168	PHOSPHORYLATION	561	S	PhosphoSitePlus	3213486	LTP	N
HuLPr04168	PHOSPHORYLATION	562	S	PhosphoSitePlus	3213489	LTP	N
HuLPr04168	PHOSPHORYLATION	658	S	PhosphoSitePlus	3213492	LTP	N
HuLPr04168	PHOSPHORYLATION	661	S	PhosphoSitePlus	3213495	LTP	N
HuLPr04168	PHOSPHORYLATION	664	S	PhosphoSitePlus	3213498	LTP	N
HuLPr04168	PHOSPHORYLATION	72	S	PhosphoSitePlus	3213501	LTP	N
HuLPr04168	PHOSPHORYLATION	927	S	PhosphoSitePlus	3213504	LTP	N
HuLPr04168	PHOSPHORYLATION	327	T	PhosphoSitePlus	3213513	LTP HTP	N
HuLPr04168	PHOSPHORYLATION	397	T	PhosphoSitePlus	3213519	LTP	N
HuLPr04168	PHOSPHORYLATION	671	Y	PhosphoSitePlus	450421	LTP	N
HuLPr04168	PHOSPHORYLATION	189	S	PhosphoSitePlus	5364608	LTP	N
HuLPr04168	PHOSPHORYLATION	294	T	PhosphoSitePlus	5364609	HTP	N
HuLPr04168	PHOSPHORYLATION	320	T	PhosphoSitePlus	472549	LTP	N
HuLPr04168	PHOSPHORYLATION	54	S	PhosphoSitePlus	486549	LTP	N
HuLPr04168	PHOSPHORYLATION	364	T	PhosphoSitePlus	486551	LTP HTP	N
HuLPr04168	PHOSPHORYLATION	483	T	PhosphoSitePlus	12673100	LTP	N
HuLPr04168	PHOSPHORYLATION	182	S	PhosphoSitePlus	483856	LTP	N
HuLPr04168	PHOSPHORYLATION	449	S	PhosphoSitePlus	483857	LTP	N
HuLPr04168	PHOSPHORYLATION	194	T	PhosphoSitePlus	483858	LTP	N
HuLPr04168	PHOSPHORYLATION	401	T	PhosphoSitePlus	483859	LTP	N