Protein basic information
| LiverAtlas Protein ID |
HuLPr04225 |
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Uniprot ID |
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Uniprot Acc |
P01008;B2R6P0;P78439;P78447;Q13815;Q5TC78;Q7KZ43;Q7KZ97;Q9UC78; |
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Protein name |
Antithrombin-III |
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Comment |
FUNCTION:Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.||INTERACTION:P19174:PLCG1; NbExp=1; IntAct=EBI-1039832, EBI-79387;||SUBCELLULAR LOCATION:Secreted, extracellular space.||TISSUE SPECIFICITY:Found in plasma.||PTM:Phosphorylation sites are present in the extracelllular medium.||MASS SPECTROMETRY:Mass=57863; Method=Electrospray; Range=33-464; Source=PubMed:7734359;||MASS SPECTROMETRY:Mass=57911; Method=Electrospray; Range=33-464; Note=Variant Thr-414; Source=PubMed:7734359;||DISEASE:Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I:characterized by a 50% decrease in antigenic and functional le |
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Subcellular localization |
Secreted, extracellular space. |
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Gene name |
serpin peptidase inhibitor, clade C (antithrombin), member 1 |
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Related liver disease name |
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Protein sequence
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MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDIC TAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRR VWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTA FAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAK LNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISEL VYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIP SEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKA DGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITM VLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHM PRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGR DDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPN RVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK |
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Database cross reference |
RefSeq Protein accession:NP_000479
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Liver relevance
| Liver sepcificity |
Yes/No |
Yes |
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Evidence |
BodyMap |
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Quality score |
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005615;C:extracellular space;IDA:BHF-UCL. GO:0005886;C:plasma membrane;EXP:Reactome. |
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GO-F |
GO:0008201;F:heparin binding;IEA:UniProtKB-KW. GO:0002020;F:protease binding;IPI:UniProtKB. GO:0004867 |