HuLPr04244

Uniprot ID

AOC3_HUMAN

Uniprot Acc

Q16853;B2RCI5;Q45F94;

Protein name

Membrane primary amine oxidase

Comment

FUNCTION:Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis.||CATALYTIC ACTIVITY:RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).||COFACTOR:Binds 1 copper ion per subunit.||COFACTOR:Binds 2 calcium ions per subunit.||COFACTOR:Contains 1 topaquinone per subunit.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=1.94 mM for 2-phenylethylamine; KM=0.67 mM for methylamine;||SUBUNIT:Homodimer; disulfide-linked. Forms heterodimer with AOC2.||SUBCELLULAR LOCATION:Membrane; Single-pass type II membrane protein.||TISSUE SPECIFICITY:Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, p

Subcellular localization

Membrane;Single-pass type II membrane protein.

Gene name

amine oxidase, copper containing 3 (vascular adhesion protein 1)

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPH CPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFLTQRL GPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSP PPAREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTV ERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLLH HCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISG AGFFLHHVGLELLVNHKALDPARWTIQKVFYQGRYYDSL AQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPPGPAPP LQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDV RFQGERLVYEISLQEALAIYGGNSPAAMTTRYVDGGFGM GKYTTPLTRGVDCPYLATYVDWHFLLESQAPKTIRDAFC VFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLL NYDYVWDTVFHPSGAIEIRFYATGYISSAFLFGATGKYG NQVSEHTLGTVHTHSAHFKVDLDVAGLENWVWAEDMVFV PMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRY LYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGF SWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDFSDFI NNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGF FLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLACL PQAAACAPDLPAFSHGGFSHN

Database cross reference

RefSeq Protein accession:NP_003725
RefSeq Protein gi:4502119

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0009986;C:cell surface;IDA:UniProtKB. GO:0016021;C:integral to membrane;IDA:UniProtKB. GO:0005886;C:plasma membrane;IDA:UniProtKB.

GO-F

GO:0052595;F:aliphatic-amine oxidase activity;IEA:EC. GO:0052594;F:aminoacetone:oxygen oxidoreductase(deaminating) activity;IEA:EC. GO:0005507;F:copper ion binding;TAS:UniProtKB. GO:0052596;F:phenethylamine:oxygen oxidoreductase (deaminating) activity;I

GO-P

GO:0009308;P:amine metabolic process;IDA:UniProtKB. GO:0007155;P:cell adhesion;IDA:UniProtKB. GO:0006954;P:inflammatory response;TAS:UniProtKB. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW.