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Protein basic information

LiverAtlas Protein ID

HuLPr04297

Uniprot ID

APCD1_HUMAN

Uniprot Acc

Q8J025;B4DUQ0;B4DZT0;Q71M25;

Protein name

Protein APCDD1

Comment

FUNCTION:Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.||SUBUNIT:Homodimer. Interacts with LRP5 and WNT3A.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type I membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8J025-1; Sequence=Displayed; Name=2; IsoId=Q8J025-2; Sequence=VSP 039542; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).||INDUCTION:Target gene of

Subcellular localization

Cell membrane;Single-pass type I membrane protein.

Gene name

adenomatosis polyposis coli down-regulated 1

Protein sequence

MSWPRRLLLRYLFPALLLHGLGEGSALLHPDSRSHPRSLE KSAWRAFKESQCHHMLKHLHNGARITVQMPPTIEGHWVS TGCEVRSGPEFITRSYRFYHNNTFKAYQFYYGSNRCTNP TYTLIIRGKIRLRQASWIIRGGTEADYQLHNVQVICHTE AVAEKLGQQVNRTCPGFLADGGPWVQDVAYDLWREENGC ECTKAVNFAMHELQLIRVEKQYLHHNLDHLVEELFLGDI HTDATQRMFYRPSSYQPPLQNAKNHDHACIACRIIYRSD EHHPPILPPKADLTIGLHGEWVSQRCEVRPEVLFLTRHF IFHDNNNTWEGHYYHYSDPVCKHPTFSIYARGRYSRGVL SSRVMGGTEFVFKVNHMKVTPMDAATASLLNVFNGNECG AEGSWQVGIQQDVTHTNGCVALGIKLPHTEYEIFKMEQD ARGRYLLFNGQRPSDGSSPDRPEKRATSYQMPLVQCASS SPRAEDLAEDSGSSLYGRAPGRHTWSLLLAALACLVPLLHWNIRR

Database cross reference

RefSeq Protein accession:NP_694545
RefSeq Protein gi:23308597

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005887;C:integral to plasma membrane;IDA:UniProtKB.

GO-F

GO:0017147;F:Wnt-protein binding;IDA:UniProtKB.

GO-P

GO:0001942;P:hair follicle development;IMP:UniProtKB. GO:0030178;P:negative regulation of Wnt receptor signaling pathway;IDA:UniProtKB. GO:0016055;P:Wnt receptor signaling pathway;IEA:UniProtKB-KW.