HuLPr04304

Uniprot ID

APLD1_HUMAN

Uniprot Acc

Q96LR9;Q8IVR2;Q9H0I5;

Protein name

Apolipoprotein L domain-containing protein 1

Comment

FUNCTION:May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood- brain permeability.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96LR9-1; Sequence=Displayed; Note=No experimental confirmation available; Name=2; IsoId=Q96LR9-2; Sequence=VSP 019960;||TISSUE SPECIFICITY:Expressed in neonatal dermal microvascular endothelial cells.||INDUCTION:In neonatal dermal microvascular endothelial cells, by hypoxia.||SIMILARITY:Belongs to the apolipoprotein L family.||SEQUENCE CAUTION:Sequence=AAH42478.1; Type=Erroneous initiation;

Subcellular localization

Cell membrane;Multi-pass membrane protein(Probable).

Gene name

apolipoprotein L domain containing 1

Protein sequence

MFRAPCHRLRARGTRKARAGAWRGCTFPCLGKGMERPAAR EPHGPDALRRFQGLLLDRRGRLHGQVLRLREVARRLERL RRRSLVANVAGSSLSATGALAAIVGLSLSPVTLGTSLLV SAVGLGVATAGGAVTITSDLSLIFCNSRELRRVQEIAAT CQDQMREILSCLEFFCRWQGCGDRQLLQCGRNASIALYN SVYFIVFFGSRGFLIPRRAEGDTKVSQAVLKAKIQKLAE SLESCTGALDELSEQLESRVQLCTKSSRGHDLKISADQRAGLFF

Database cross reference

RefSeq Protein accession:NP_001123887
RefSeq Protein gi:194353995

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005576;C:extracellular region;IEA:InterPro. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0008289;F:lipid binding;IEA:InterPro.

GO-P

GO:0001525;P:angiogenesis;IEA:UniProtKB-KW. GO:0030154;P:cell differentiation;IEA:UniProtKB-KW. GO:0006869;P:lipid transport;IEA:InterPro. GO:0042157;P:lipoprotein metabolic process;IEA:InterPro.