HuLPr04314

Uniprot ID

APOB_HUMAN

Uniprot Acc

P04114;O00502;P78479;P78480;P78481;Q13779;Q13785;Q13786;Q13787;Q13788;Q4ZG63;Q53QC8;Q7Z600;Q9UMN0;

Protein name

Apolipoprotein B-100

Comment

FUNCTION:Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.||SUBCELLULAR LOCATION:Secreted.||INDUCTION:Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).||PTM:Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.||RNA EDITING:Modified positions=2180; Note=The stop codon (UAA) at position 2180 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B- 100) is produced by the liver and is found in the VLDL and LDL.||DISEASE:Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 (FHBL1) [MIM:107730]. A disorder charac

Subcellular localization

Secreted.

Gene name

apolipoprotein B (including Ag(x) antigen)

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCP KDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCK VELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKN SEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIK RGIISALLVPPETEEAKQVLFLDTVYGNCSTHFTVKTRK GNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPL STLISSSQSCQYTLDAKRKHVAEAICKEQHLFLPFSYKN KYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFEST KSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLV TELRGLSDEAVTSLLPQLIEVSSPITLQALVQCGQPQCS THILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIF NMARDQRSRATLYALSHAVNNYHKTNPTGTQELLDIANY LMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKS SILKCVQSTKPSLMIQKAAIQALRKMEPKDKDQEVLLQT FLDDASPGDKRLAAYLMLMRSPSQADINKIVQILPWEQN EQVKNFVASHIANILNSEELDIQDLKKLVKEALKESQLP TVMDFRKFSRNYQLYKSVSLPSLDPASAKIEGNLIFDPN NYLPKESMLKTTLTAFGFASADLIEIGLEGKGFEPTLEA LFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTK DDKHEQDMVNGIMLSVEKLIKDLKSKEVPEARAYLRILG EELGFASLHDLQLLGKLLLMGARTLQGIPQMIGEVIRKG SKNDFFLHYIFMENAFELPTGAGLQLQISSSGVIAPGAK AGVKLEVANMQAELVAKPSVSVEFVTNMGIIIPDFARSG VQMNTNFFHESGLEAHVALKAGKLKFIIPSPKRPVKLLS GGNTLHLVSTTKTEVIPPLIENRQSWSVCKQVFPGLNYC TSGAYSNASSTDSASYYPLTGDTR

Database cross reference

RefSeq Protein accession:NP_000375
RefSeq Protein gi:105990532

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0034360;C:chylomicron remnant;TAS:BHF-UCL. GO:0030669;C:clathrin-coated endocytic vesicle membrane;EXP:Reactome. GO:0005788;C:endoplasmic reticulum lumen;EXP:Reactome. GO:0005789;C:endoplasmic reticulum membrane;TAS:Reactome. GO:0031904;C:endosome l

GO-F

GO:0017127;F:cholesterol transporter activity;IMP:BHF-UCL. GO:0019899;F:enzyme binding;IPI:BHF-UCL. GO:0008201;F:heparin binding;IDA:BHF-UCL. GO:0050750;F:low-density lipoprotein particle receptor binding;IMP:BHF-UCL. GO:0005543;F:phospholipid binding;