Protein basic information
| LiverAtlas Protein ID |
HuLPr04321 |
|
Uniprot ID |
|
|
Uniprot Acc |
P02649;B2RC15;C0JYY5;Q9P2S4; |
|
Protein name |
Apolipoprotein E |
|
Comment |
FUNCTION:Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.||INTERACTION:Q16543:CDC37; NbExp=1; IntAct=EBI-1222467, EBI-295634; Q9BQ95:ECSIT; NbExp=1; IntAct=EBI-1222467, EBI-712452; Q53EL6:PDCD4; NbExp=1; IntAct=EBI-1222467, EBI-935824; P50502:ST13; NbExp=1; IntAct=EBI-1222467, EBI-357285;||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.||PTM:Synthesized with the sialic acid attached by O-glycosidic linkage and is subsequently desialylated in plasma. O-glycosylated with core 1 or possibly core 8 glycans. Thr-307 is a minor glycosylation s |
|
Subcellular localization |
Secreted. |
|
Gene name |
|
|
Related liver disease name |
|
|
Protein sequence
|
MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQS GQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELR ALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLAS HLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIR ERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRAR MEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEA FQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH |
|
Database cross reference |
RefSeq Protein accession:NP_000032
|
Liver relevance
| Liver sepcificity |
Yes/No |
Yes |
|
Evidence |
Translational level from literatures |
|
|
Quality score |
|
|
|
HCC significant Proteins |
Yes/No |
Yes |
|
Quality score |
|
|
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0042627;C:chylomicron;IDA:BHF-UCL. GO:0030425;C:dendrite;NAS:BHF-UCL. GO:0034364;C:high-density lipoprotein particle;IDA:BHF-UCL. GO:0034363;C:intermediate-density lipoprotein particle;IDA:BHF-UCL. GO:0034362;C:low-density lipoprotein particle;IDA:B |
|
GO-F |
GO:0016209;F:antioxidant activity;IDA:BHF-UCL. GO:0001540;F:beta-amyloid binding;IDA:UniProtKB. GO:0008201;F:heparin binding;IDA:BHF-UCL. GO:0 |