Protein basic information
| LiverAtlas Protein ID |
HuLPr04349 |
|
Uniprot ID |
|
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Uniprot Acc |
O43315;Q9NP32; |
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Protein name |
Aquaporin-9 |
|
Comment |
FUNCTION:Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen.||DOMAIN:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).||SIMILARITY:Belongs to the MIP/aquaporin (TC 1.A.8) family. |
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Subcellular localization |
Membrane;Multi-pass membrane protein. |
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Gene name |
|
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Protein sequence
|
MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLG CGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVS GGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAA TVFGIYYDGLMSFAGGKLLIVGENATAHIFATYPAPYLS LANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIAI GLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFE VFRAGNNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPD SVFKTEQSEDKPEKYELSVIM |
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Database cross reference |
RefSeq Protein accession:NP_066190
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005887;C:integral to plasma membrane;TAS:ProtInc. GO:0043231;C:intracellular membrane-bounded organelle;IDA:UniProtKB. |
|
GO-F |
GO:0005275;F:amine transmembrane transporter activity;TAS:UniProtKB. GO:0046943;F:carboxylic acid transmembrane transporter activity;TAS:UniProtKB. GO:0015254;F:glycerol channel activity;TAS:Reactome. GO:0015288;F:porin activity;NAS:UniProtKB. GO:00053 |
|
GO-P |
GO:0071320;P:cellular response to cAMP;IEP:UniProtKB. GO:0007588;P:excretion;TAS:UniProtKB. GO:0006955;P:immune response;TAS:ProtInc. GO:0008152;P:metabolic process;TAS:UniProtKB. GO:0046689;P:response to mercury ion;IDA:UniProtKB. GO:0006970;P:respon |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr04349 |
PHOSPHORYLATION |
11 |
S |
Phospho-ELM |
LTP |
N |
 
|
|
|
HuLPr04349 |
PHOSPHORYLATION |
222 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr04349 |
PHOSPHORYLATION |
11 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr04349 |
PHOSPHORYLATION |
222 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
