HuLPr04375

Uniprot ID

ARFG2_HUMAN

Uniprot Acc

Q8N6H7;D3DQQ9;Q3LIF2;Q8N3I1;Q96SX7;

Protein name

ADP-ribosylation factor GTPase-activating protein 2

Comment

FUNCTION:GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.||SUBUNIT:Interacts with the coatomer complex. Interacts with the C-terminal appendage domain of COPG.||SUBCELLULAR LOCATION:Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum- Golgi intermediate compartment.||MISCELLANEOUS:Vero cells overexpressing truncated ARFGAP2 show accumulation of cholera toxin A subunit in the Golgi complex rather than the endoplasmic reticulum.||SIMILARITY:Contains 1 Arf-GAP domain.

Subcellular localization

Cytoplasm.Golgi apparatus membrane;Peripheral membrane protein;Cytoplasmic side.

Gene name

ADP-ribosylation factor GTPase activating protein 2

Protein sequence

MAAEPNKTEIQTLFKRLRAVPTNKACFDCGAKNPSWASIT YGVFLCIDCSGVHRSLGVHLSFIRSTELDSNWNWFQLRC MQVGGNANATAFFRQHGCTANDANTKYNSRAAQMYREKI RQLGSAALARHGTDLWIDNMSSAVPNHSPEKKDSDFFTE HTQPPAWDAPATEPSGTQQPAPSTESSGLAQPEHGPNTD LLGTSPKASLELKSSIIGKKKPAAAKKGLGAKKGLGAQK VSSQSFSEIERQAQVAEKLREQQAADAKKQAEESMVASM RLAYQELQIDRKKEEKKLQNLEGKKREQAERLGMGLVSR SSVSHSVLSEMQVIEQETPVSAKSSRSQLDLFDDVGTFA SGPPKYKDNPFSLGESFGSRWDTDAAWGMDRVEEKEPEV TISSIRPISERATNRREVESRSSGLESSEARQKFAGAKA ISSDMFFGREVDAEYEARSRLQQLSGSSAISSSDLFGDM DGAHGAGSVSLGNVLPTADIAQFKQGVKSVAGKMAVLAN GVMNSLQDRYGSY

Database cross reference

RefSeq Protein accession:NP_115765
RefSeq Protein gi:31543983

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0005730;C:nucleolus;IDA:HPA. GO:0005886;C:plasma membrane;IDA:HPA.

GO-F

GO:0008060;F:ARF GTPase activator activity;IEA:InterPro. GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0015031;P:protein transport;IEA:UniProtKB-KW. GO:0032312;P:regulation of ARF GTPase activity;IEA:InterPro. GO:0016192;P:vesicle-mediated transport;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr04375

PHOSPHORYLATION

146

S

Phospho-ELM

10717

HTP

yes

HuLPr04375

PHOSPHORYLATION

180

S

Phospho-ELM

37243

HTP

N

HuLPr04375

PHOSPHORYLATION

201

S

Phospho-ELM

37244

HTP

N

HuLPr04375

PHOSPHORYLATION

368

S

Phospho-ELM

37245

HTP

yes

HuLPr04375

PHOSPHORYLATION

432

S

Phospho-ELM

37246

HTP

N

HuLPr04375

PHOSPHORYLATION

498

S

Phospho-ELM

10718

HTP

N

HuLPr04375

PHOSPHORYLATION

146

S

PhosphoSitePlus

469075

LTP

yes

HuLPr04375

PHOSPHORYLATION

432

S

PhosphoSitePlus

469076

LTP

N

HuLPr04375

PHOSPHORYLATION

314

S

PhosphoSitePlus

4771322

LTP

N

HuLPr04375

PHOSPHORYLATION

8

T

PhosphoSitePlus

18017969

LTP

HTP

N

HuLPr04375

PHOSPHORYLATION

278

Y

PhosphoSitePlus

464499

LTP

N

HuLPr04375

PHOSPHORYLATION

498

S

PhosphoSitePlus

470638

LTP

HTP

N

HuLPr04375

PHOSPHORYLATION

368

S

PhosphoSitePlus

3206391

LTP

yes

HuLPr04375

PHOSPHORYLATION

140

S

PhosphoSitePlus

14567936

LTP

yes

HuLPr04375

PHOSPHORYLATION

445

Y

PhosphoSitePlus

450784

LTP

HTP

N

HuLPr04375

PHOSPHORYLATION

340

S

PhosphoSitePlus

477914

LTP

N

ID