Protein basic information
| LiverAtlas Protein ID |
HuLPr04417 |
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Uniprot ID |
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Uniprot Acc |
Q4LE39;A1L465;Q3MHV4;Q5HY99;Q5T2C2;Q5T2C3;Q5T2C4;Q5T2C5;Q5T2C6;Q6P600;Q86UX1;Q86WR4;Q9H915;Q9NYU3;Q9NZB6;Q9NZG4;Q9P2W4;Q9UF62;Q9Y6E1; |
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Protein name |
AT-rich interactive domain-containing protein 4B |
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Comment |
FUNCTION:Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.||SUBUNIT:Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.||INTERACTION:P14921:ETS1; NbExp=1; IntAct=EBI-2680990, EBI-913209;||SUBCELLULAR LOCATION:Nucleus (By similarity). Cytoplasm. Note=Cytoplasmic in breast cancer cells.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q4LE39-1; Sequence=Displayed; Name=2; IsoId=Q4LE39-2; Sequence=VSP 024231; Name=3; IsoId=Q4LE39-3; Sequence=VSP 024234, VSP 024235; Name=4; IsoId=Q4LE39-4; Sequence=VSP 024230, VSP 024232, VSP 024233;||TISSUE SPECIFICITY:Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.||DOMAIN:The C-terminus mediates interacti |
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Subcellular localization |
Nucleus(By similarity).Cytoplasm. |
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Gene name |
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Protein sequence
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MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKV TFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAV INKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESE TLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSS SSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALV VCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITS DTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSS SSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFL QQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGG FDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLY GFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKE ENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSL GSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTT RVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEE EEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQK MYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIV RPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRR LSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSI LNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLT NNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPER LRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQI KRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSN SSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGF SEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPK KTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEE SCSPSVELEKPPPVNVDSKPIEEK |
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Database cross reference |
RefSeq Protein accession:NP_057458
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0000785;C:chromatin;IEA:InterPro. GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0003682;F:chromatin binding;IEA:InterPro. GO:0003677;F:DNA binding;IEA:UniProtKB-KW. GO:0005515;F:protein binding;IPI:IntAct. |
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GO-P |
GO:0006333;P:chromatin assembly or disassembly;IEA:InterPro. GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr04417 |
PHOSPHORYLATION |
1022 |
T |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1029 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1150 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1152 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1153 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1155 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1159 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
666 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
675 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
778 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
790 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
793 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
912 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr04417 |
SUMOYLATION |
440 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr04417 |
SUMOYLATION |
429 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
507 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
508 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
133 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1031 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
ACETYLATION |
878 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1256 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1014 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1026 |
T |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
778 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1032 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1036 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
295 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
296 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
790 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1152 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1153 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1155 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1159 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
666 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
675 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
912 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1150 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1029 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
1022 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04417 |
PHOSPHORYLATION |
793 |
T |
PhosphoSitePlus |
LTP |
N |
|
