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Protein basic information

LiverAtlas Protein ID

HuLPr04440

Uniprot ID

ARL8A_HUMAN

Uniprot Acc

Q96BM9;B3KXD0;

Protein name

ADP-ribosylation factor-like protein 8A

Comment

FUNCTION:May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).||SUBCELLULAR LOCATION:Late endosome membrane. Lysosome membrane.||TISSUE SPECIFICITY:Ubiquitously expressed.||SIMILARITY:Belongs to the small GTPase superfamily. Arf family.

Subcellular localization

Late endosome membrane.Lysosome membrane.

Gene name

ADP-ribosylation factor-like 8A

Protein sequence

MIALFNKLLDWFKALFWKEEMELTLVGLQYSGKTTFVNVI ASGQFNEDMIPTVGFNMRKITKGNVTIKLWDIGGQPRFR SMWERYCRGVSAIVYMVDAADQEKIEASKNELHNLLDKP QLQGIPVLVLGNKRDLPGALDEKELIEKMNLSAIQDREI CCYSISCKEKDNIDITLQWLIQHSKSRRS

Database cross reference

RefSeq Protein accession:NP_620150
RefSeq Protein gi:20270343

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0031902;C:late endosome membrane;IEA:UniProtKB-SubCell. GO:0005765;C:lysosomal membrane;IEA:UniProtKB-SubCell. GO:0030496;C:midbody;IDA:UniProtKB. GO:0051233;C:spindle midzone;IDA:UniProtKB.

GO-F

GO:0043014;F:alpha-tubulin binding;ISS:UniProtKB. GO:0048487;F:beta-tubulin binding;ISS:UniProtKB. GO:0005525;F:GTP binding;IDA:UniProtKB. GO:0003924;F:GTPase activity;NAS:UniProtKB.

GO-P

GO:0051301;P:cell division;IEA:UniProtKB-KW. GO:0007059;P:chromosome segregation;ISS:UniProtKB. GO:0007067;P:mitosis;IEA:UniProtKB-KW. GO:0007264;P:small GTPase mediated signal transduction;IEA:InterPro.