Protein basic information
| LiverAtlas Protein ID |
HuLPr04484 |
|
Uniprot ID |
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Uniprot Acc |
Q96B67;A8K6T8;Q9P2H1; |
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Protein name |
Arrestin domain-containing protein 3 |
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Comment |
SUBUNIT:Does not bind TXN (thioredoxin).||INTERACTION:P16144:ITGB4; NbExp=1; IntAct=EBI-2875665, EBI-948678;||SUBCELLULAR LOCATION:Cytoplasm. Note=Associated with plasma membrane, as well as with endodomes and lysosomes during endocytosis.||TISSUE SPECIFICITY:Highly expressed in skeletal muscle, placenta, kidney, adrenal gland, lymph node, mammary gland, thyroid, and trachea. Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow. Strong expression in differentiated adipocytes compared to preadipocytes.||INDUCTION:By troglitazone and pioglitazone (selective PPARG agonists), by prostaglandin J2 (PGJ2) and by L165,041 (a PPARD ligand), by vitamin D3 and, to a lesser extent, by phorbol myristate acetate (PMA) in the promyelocytic leukemia HL-60 cells. No induction by retinoic acid, nor by clofibrate (a specific PPARA agonist).||SIMILARITY:Belongs to the arrestin family.||SEQUENCE CAUTION:Sequence=BAA92614.1; Type=Erroneous initiation; |
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Subcellular localization |
Cytoplasm. |
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Gene name |
|
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Protein sequence
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MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTG EIRVKSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEEV EYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFEL PQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFT VFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAK IERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFY AKGKMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVS PSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIGTIP LHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEV VTEEQRRNNLAPVSACDDFERALQGPLFAYIQEFRFLPP PLYSEIDPNPDQSADDRPSCPSR |
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Database cross reference |
RefSeq Protein accession:NP_065852
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Fetal Liver; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0005515;F:protein binding;IPI:IntAct. |
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GO-P |
GO:0007165;P:signal transduction;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr04484 |
PHOSPHORYLATION |
382 |
Y |
PhosphoSitePlus |
LTP |
N |
 
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