Protein basic information
| LiverAtlas Protein ID |
HuLPr04510 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q8TDY4;B3KRW0;B4DHH4;Q6P9F4;Q86UY1;Q9NXK2; |
|
Protein name |
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 |
|
Comment |
FUNCTION:Promotes cell proliferation.||SUBCELLULAR LOCATION:Cytoplasm.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TDY4-1; Sequence=Displayed; Name=2; IsoId=Q8TDY4-2; Sequence=VSP 018013; Note=No experimental confirmation available; Name=3; IsoId=Q8TDY4-3; Sequence=VSP 039827; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes.||SIMILARITY:Contains 2 ANK repeats.||SIMILARITY:Contains 1 Arf-GAP domain.||SIMILARITY:Contains 1 PH domain. |
|
Subcellular localization |
Cytoplasm. |
|
Gene name |
|
|
Protein sequence
|
MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALA REEILEGDQAILQRIKKAVRAIHSSGLGHVENEEQYREA VESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQ NLNNIVSFPLDSLMKGQLRDGRQDSKKQLEKAWKDYEAK MAKLEKERDRARVTGGIPGEVAQDMQRERRIFQLHMCEY LLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQS LFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGTLQL ESREEHLSRKNSGCGYSIHQHQGNKQFGTEKVGFLYKKS DGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQ VRPNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQN SKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLIA EVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHR ELGVRFSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEA QLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCTPE PQRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPE ELVLHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTA LHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARK KHHKECEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSE EDEEEKRCLLKLPAQAHWASGRLDISNKTYETVASLGAA TPQGESEDCPPPLPVKNSSRTLVQGCARHASGDRSEVSS LSSEAPETPESLGSPASSSSLMSPLEPGDPSQAPPNSEE GLREPPGTSRPSLTSGTTPSEMYLPVRFSSESTRSYRRG ARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSLPASSVQLLQD |
|
Database cross reference |
RefSeq Protein accession:NP_001137250
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. |
|
GO-F |
GO:0008060;F:ARF GTPase activator activity;IEA:InterPro. GO:0008270;F:zinc ion binding;IEA:InterPro. |
|
GO-P |
GO:0032312;P:regulation of ARF GTPase activity;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr04510 |
PHOSPHORYLATION |
530 |
Y |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr04510 |
PHOSPHORYLATION |
535 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04510 |
PHOSPHORYLATION |
733 |
Y |
PhosphoSitePlus |
LTP |
N |
|
