HuLPr04536

Uniprot ID

ASGL1_HUMAN

Uniprot Acc

Q7L266;B2R7Q0;Q567Q4;Q6P1P0;Q8NI34;Q9H6F7;

Protein name

L-asparaginase

Comment

FUNCTION:Acts in asparagine catabolism. May be involved in astroglial production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions (By similarity).||CATALYTIC ACTIVITY:L-asparagine + H(2)O = L-aspartate + NH(3).||SUBCELLULAR LOCATION:Cytoplasm. Note=Midpiece of sperm tail.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7L266-1; Sequence=Displayed; Name=2; IsoId=Q7L266-2; Sequence=VSP 028287; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma.||INDUCTION:By 5-alpha-di-hydrotestosterone and progesterone.||SIMILARITY:Belongs to the Ntn-hydrolase family.||SEQUENCE CAUTION:Sequence=BAB15302.1; Type=Erroneous initiation;

Subcellular localization

Cytoplasm.

Gene name

asparaginase like 1

Protein sequence

MNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILRE GGSAVDAVEGAVVALEDDPEFNAGCGSVLNTNGEVEMDA SIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLT DQGAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHEKGA QKTDCQKNLGTVGAVALDCKGNVAYATSTGGIVNKMVGR VGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTL FHIEQGKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDW VAKWTSTSMPWAAAKDGKLHFGIDPDDTTITDLP

Database cross reference

RefSeq Protein accession:NP_001077395
RefSeq Protein gi:145275202

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;ISS:UniProtKB. GO:0015630;C:microtubule cytoskeleton;IDA:HPA. GO:0005634;C:nucleus;IDA:HPA.

GO-F

GO:0003948;F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity;ISS:UniProtKB.

GO-P

GO:0033345;P:asparagine catabolic process via L-aspartate;ISS:UniProtKB. GO:0051604;P:protein maturation;ISS:RefGenome.

Ammonia_Recycling

Aspartate_Metabolism

Hypoacetylaspartia