Protein basic information
| LiverAtlas Protein ID |
HuLPr04553 |
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Uniprot ID |
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Uniprot Acc |
Q12797;A6NDF4;A6NHI2;Q9H2C4;Q9NRI0;Q9NRI1;Q9Y4J0; |
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Protein name |
Aspartyl/asparaginyl beta-hydroxylase |
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Comment |
FUNCTION:Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.||CATALYTIC ACTIVITY:Peptide L-aspartate + 2-oxoglutarate + O(2) = peptide 3-hydroxy-L-aspartate + succinate + CO(2).||COFACTOR:Iron.||SUBUNIT:Monomer (By similarity).||SUBCELLULAR LOCATION:Isoform 1:Endoplasmic reticulum membrane; Single-pass type II membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q12797-1; Sequence=Displayed; Name=Junctate; IsoId=Q12797-2; Sequence=VSP 039169, VSP 039170; Name=Junctin-1; Synonyms=Cardiac junctin; IsoId=Q12797-3; Sequence=VSP 039165, VSP 039166, VSP 039167, VSP 039168; Note=Glycosylated on Asn-64; Name=Junctin-2; IsoId=Q12797-4; Sequence=VSP 039165, VSP 039167, VSP 039168;||TISSUE SPECIFICITY:Isoform 1 is detected in all tissues tested.||SIMILARITY:Belongs to the aspartyl/asparaginyl beta-hydroxylase family.||SIMILARITY:Contains 4 |
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Subcellular localization |
Isoform 1:Endoplasmic reticulum membrane;Single-pass type II membrane protein. |
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Gene name |
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Protein sequence
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MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGG HKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVD YEEVLGKLGIYDADGDGDFDVDDAKVLLGLKERSTSEPA VPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHE MVHAEHVEGEDLQQEDGPTGEPQQEDDEFLMATDVDDRF ETLEPEVSHEETEHSYHVEETVSQDCNQDMEEMMSEQEN PDSSEPVVEDERLHHDTDDVTYQVYEEQAVYEPLENEGI EITEVTAPPEDNPVEDSQVIVEEVSIFPVEEQQEVPPET NRKTDDPEQKAKVKKKKPKLLNKFDKTIKAELDAAEKLR KRGKIEEAVNAFKELVRKYPQSPRARYGKAQCEDDLAEK RRSNEVLRGAIETYQEVASLPDVPADLLKLSLKRRSDRQ QFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGD NDNAKKVYEEVLSVTPNDGFAKVHYGFILKAQNKIAESI PYLKEGIESGDPGTDDGRFYFHLGDAMQRVGNKEAYKWY ELGHKRGHFASVWQRSLYNVNGLKAQPWWTPKETGYTEL VKSLERNWKLIRDEGLAVMDKAKGLFLPEDENLREKGDW SQFTLWQQGRRNENACKGAPKTCTLLEKFPETTGCRRGQ IKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIR CANETKTWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPAI |
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Database cross reference |
RefSeq Protein accession:NP_001158222
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0030176;C:integral to endoplasmic reticulum membrane;IEA:InterPro. |
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GO-F |
GO:0005509;F:calcium ion binding;TAS:ProtInc. GO:0009055;F:electron carrier activity;TAS:UniProtKB. GO:0016702;F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;IEA:UniProtKB-K |
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GO-P |
GO:0006936;P:muscle contraction;TAS:ProtInc. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr04553 |
PHOSPHORYLATION |
29 |
S |
Phospho-ELM |
HTP |
N |
 
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HuLPr04553 |
PHOSPHORYLATION |
9 |
S |
PhosphoSitePlus |
LTP |
N |
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|
|
HuLPr04553 |
PHOSPHORYLATION |
10 |
S |
PhosphoSitePlus |
LTP |
N |
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|
HuLPr04553 |
PHOSPHORYLATION |
22 |
S |
PhosphoSitePlus |
LTP |
N |
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|
|
HuLPr04553 |
PHOSPHORYLATION |
23 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04553 |
PHOSPHORYLATION |
24 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04553 |
PHOSPHORYLATION |
27 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04553 |
PHOSPHORYLATION |
28 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr04553 |
PHOSPHORYLATION |
29 |
S |
PhosphoSitePlus |
LTP |
N |
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