HuLPr04581

Uniprot ID

AT1A1_HUMAN

Uniprot Acc

P05023;B2RBR6;Q16689;Q6LDM4;Q9UCN1;Q9UJ20;Q9UJ21;

Protein name

Sodium/potassium-transporting ATPase subunit alpha-1

Comment

FUNCTION:This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.||CATALYTIC ACTIVITY:ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).||SUBUNIT:Composed of three subunits:alpha (catalytic), beta and gamma. Binds the HLA class II histocompatibility antigen, DR1.||INTERACTION:Q92597:NDRG1; NbExp=1; IntAct=EBI-358778, EBI-716486;||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P05023-1; Sequence=Displayed; Name=Short; IsoId=P05023-2; Sequence=VSP 000415, VSP 000416; Note=May be produced at very low

Subcellular localization

Cell membrane;Multi-pass membrane protein.Melanosome.

Gene name

ATPase, Na+/K+ transporting, alpha 1 polypeptide

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVS MDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNA LTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQ AATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKI MESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGG DRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNEN PLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLA SGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLIL EYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMA RKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHM WFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNR AVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKE MRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMK GAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGG LGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFV GLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAK AIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACV VHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVE GCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVS KQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLT SNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAI SLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGM IQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDV EDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVIC KTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGV ALRMYPLKPTWWFCAFPYSLLIFV

Database cross reference

RefSeq Protein accession:NP_000692
RefSeq Protein gi:21361181

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0042470;C:melanosome;IEA:UniProtKB-SubCell. GO:0005890;C:sodium:potassium-exchanging ATPase complex;TAS:ProtInc.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0005515;F:protein binding;IPI:UniProtKB. GO:0005391;F:sodium:potassium-exchanging ATPase activity;TAS:ProtInc.

GO-P

GO:0006754;P:ATP biosy Error!!!Go back to the login page