HuLPr04590

Uniprot ID

AT2A2_HUMAN

Uniprot Acc

P16615;A6NDN7;B4DF05;P16614;Q86VJ2;

Protein name

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Comment

FUNCTION:This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle.||CATALYTIC ACTIVITY:ATP + H(2)O + Ca(2+)(Cis) = ADP + phosphate + Ca(2+)(Trans).||ENZYME REGULATION:Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN (By similarity).||SUBUNIT:Associated with phospholamban (PLN) (By similarity). Isoform 1 interacts with TRAM2 (via C-terminus). Interacts with HAX1.||INTERACTION:O75365:PTP4A3; NbExp=1; IntAct=EBI-358933, EBI-1043866;||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Comment

Subcellular localization

Endoplasmic reticulum membrane;Multi-pass membrane protein.Sarcoplasmic reticulum membrane;Multi-pass membrane protein.

Gene name

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNE LPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFE EGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEA LKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGD KVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPD PRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKI RDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWII NIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPA VITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDK TGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAP IGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEA KGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERAN ACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSM SKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSV IREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKY ETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITG DNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSA QRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDG VNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTI VAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALG FPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPP RNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAAD GGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTM ALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSIC LSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPV ILMDETLKFVARNYLEPGKECVQP

Database cross reference

RefSeq Protein accession:NP_001129237
RefSeq Protein gi:209413709

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005887;C:integral to plasma membrane;TAS:ProtInc. GO:0005792;C:microsome;TAS:ProtInc. GO:0031095;C:platelet dense tubular network membrane;TAS:Reactome. GO:0033017;C:sarcoplasmic reticulum membrane;TAS:BHF-UCL.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0005388;F:calcium-transporting ATPase activity;TAS:Reactome. GO:0008022;F:protein C-terminus binding;IPI:UniProtKB. GO:0048155;F:S100 alpha binding;IPI:UniProtKB.