Protein basic information
| LiverAtlas Protein ID |
HuLPr04642 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q96DT6;A6NLR8;D3DQ58;Q96K04; |
|
Protein name |
Cysteine protease ATG4C |
|
Comment |
FUNCTION:Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.||ENZYME REGULATION:Inhibited by N-ethylmaleimide.||SUBCELLULAR LOCATION:Cytoplasm (Probable).||TISSUE SPECIFICITY:Highly expressed in skeletal muscle, heart, liver and testis.||SIMILARITY:Belongs to the peptidase C54 family.||SEQUENCE CAUTION:Sequence=BAB55356.1; Type=Frameshift; Positions=420; |
|
Subcellular localization |
Cytoplasm(Probable). |
|
Gene name |
|
|
Protein sequence
|
MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSP VLLLGKCYHFKYEDEDKTLPAESGCTIEDHVIAGNVEEF RKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQM LLAQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKF TASFEASLSGEREFKTPTISLKETIGKYSDDHEMRNEVY HRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPA VVAHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDK QSASMTSDNADDKAVIILVPVRLGGERTNTDYLEFVKGI LSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSF VDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNV QDFKRASEEITKMLKFSSKEKYPLFTFVNGHSRDYDFTS TTTNEEDLFSEDEKKQLKRFSTEEFVLL |
|
Database cross reference |
RefSeq Protein accession:NP_116241
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;ISS:UniProtKB. GO:0005576;C:extracellular region;IDA:UniProtKB. |
|
GO-F |
GO:0004197;F:cysteine-type endopeptidase activity;IMP:UniProtKB. |
|
GO-P |
GO:0000045;P:autophagic vacuole assembly;IGI:UniProtKB. GO:0006612;P:protein targeting to membrane;ISS:UniProtKB. GO:0006508;P:proteolysis;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr04642 |
PHOSPHORYLATION |
451 |
S |
PhosphoSitePlus |
HTP |
N |
 
|
|
|
HuLPr04642 |
PHOSPHORYLATION |
452 |
T |
PhosphoSitePlus |
LTP |
N |
|
