HuLPr04647

Uniprot ID

ATG9B_HUMAN

Uniprot Acc

Q674R7;A1A5D3;Q6JRW5;Q8N8I8;

Protein name

Autophagy-related protein 9B

Comment

FUNCTION:Plays a role in autophagy (By similarity).||SUBCELLULAR LOCATION:Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q674R7-1; Sequence=Displayed; Name=2; IsoId=Q674R7-2; Sequence=VSP 030410, VSP 030413; Note=No experimental confirmation available; Name=3; IsoId=Q674R7-3; Sequence=VSP 030411, VSP 030412; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial.||INDUCTION:By hypoxia, leading to inhibit NOS3 expression.||MISCELLANEOUS:ATG9B gene is located on the opposite DNA strand of the NOS3 gene at chromosome 7q36. The genes are oriented in a tail-to-tail configuration and the mRNAs encoding ATG9B and NOS3 are complementary for 662 nucleotides. ATG9B transcription may a role in NOS3 transcription regulation.||SIMILARITY:Belongs to t

Subcellular localization

Cytoplasmic vesicle, autophagosome membrane;Multi-pass membrane protein(By similarity).

Gene name

ATG9 autophagy related 9 homolog B (S. cerevisiae)

Protein sequence

MVSRMGWGGRRRRLGRWGDLGPGSVPLLPMPLPPPPPPSC RGPGGGRISIFSLSPAPHTRSSPSSFSPPTAGPPCSVLQ GTGASQSCHSALPIPATPPTQAQPAMTPASASPSWGSHS TPPLAPATPTPSQQCPQDSPGLRVGPLIPEQDYERLEDC DPEGSQDSPIHGEEQQPLLHVPEGLRGSWHHIQNLDSFF TKIYSYHQRNGFACILLEDVFQLGQFIFIVTFTTFLLRC VDYNVLFANQPSNHTRPGPFHSKVTLSDAILPSAQCAER IRSSPLLVLLLVLAAGFWLVQLLRSVCNLFSYWDIQVFY REALHIPPEELSSVPWAEVQSRLLALQRSGGLCVQPRPL TELDIHHRILRYTNYQVALANKGLLPARCPLPWGGSAAF LSRGLALNVDLLLFRGPFSLFRGGWELPHAYKRSDQRGA LAARWGRTVLLLAALNLALSPLVLAWQVLHVFYSHVELL RREPGALGARGWSRLARLQLRHFNELPHELRARLARAYR PAAAFLRTAAPPAPLRTLLARQLVFFAGALFAALLVLTV YDEDVLAVEHVLTAMTALGVTATVARSFIPEEQCQGRAP QLLLQTALAHMHYLPEEPGPGGRDRAYRQMAQLLQYRAV SLLEELLSPLLTPLFLLFWFRPRALEIIDFFHHFTVDVA GVGDICSFALMDVKRHGHPQWLSAGQTEASLSQRAEDGK TELSLMRFSLAHPLWRPPGHSSKFLGHLWGRVQQDAAAW GATSARGPSTPGVLSNCTSPLPEAFLANLFVHPLLPPRD LSPTAPCPAAATASLLASISRIAQDPSSVSPGGTGGQKL AQLPELASAEMSLHVIYLHQLHQQQQQQEPWGEAAASIL SRPCSSPSQPPSPDEEKPSWSSDGSSPASSPRQQWGTQK ARNLFPGGFQVTTDTQKEPDRASCTD

Database cross reference

RefSeq Protein accession:NP_775952
RefSeq Protein gi:239582720

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0000421;C:autophagic vacuole membrane;IEA:UniProtKB-SubCell. GO:0031410;C:cytoplasmic vesicle;IEA:UniProtKB-KW. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-P

GO:0000045;P:autophagic vacuole assembly;IDA:MGI.