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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr04666

Uniprot ID

ATP4A_HUMAN

Uniprot Acc

P20648;O00738;

Protein name

Potassium-transporting ATPase alpha chain 1

Comment

FUNCTION:Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.||CATALYTIC ACTIVITY:ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).||SUBUNIT:Composed of two subunits:alpha (catalytic) and beta.||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Found in gastric mucosa.||SIMILARITY:Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

Subcellular localization

Membrane;Multi-pass membrane protein.

Gene name

ATPase, H+/K+ exchanging, alpha polypeptide

Protein sequence

MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRK EKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLA AELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVA AAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCF GYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQL VVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEP QTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGD RTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILF GATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVT VCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGT LTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWR ALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLK FSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLED PRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWRE AFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEA MNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVI MVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVD QVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFAR TSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIG VAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFD NLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILF IELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEP LAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLR AQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISI EVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCI GCFLCYCPGMPNIFNFMPIRFQWW

Database cross reference

RefSeq Protein accession:NP_000695
RefSeq Protein gi:51944966

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005887;C:integral to plasma membrane;TAS:ProtInc.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0008900;F:hydrogen:potassium-exchanging ATPase activity;TAS:ProtInc. GO:0000287;F:magnesium ion binding;IEA:InterPro.

GO-P

GO:0006754;P:ATP biosynthetic process;IEA:InterPro. GO:0015991;P:ATP hydrolysis coupled proton transport;IEA:InterPro.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr04666

PHOSPHORYLATION

7

Y

PhosphoSitePlus

484289

LTP

HTP

N

HuLPr04666

PHOSPHORYLATION

10

Y

PhosphoSitePlus

484290

LTP

N

HuLPr04666

PHOSPHORYLATION

233

S

PhosphoSitePlus

3147207

LTP

N

HuLPr04666

PHOSPHORYLATION

237

T

PhosphoSitePlus

3147498

LTP

N

HuLPr04666

MONO-METHYLATION

31

K

PhosphoSitePlus

2099701

LTP

HTP

N

Pathway

Pathway name

Esomeprazole_Pathway

Pathway name

Omeprazole_Pathway

Pathway name

Lansoprazole_Pathway

Pathway name

Pantoprazole_Pathway

Pathway name

Rabeprazole_Pathway