HuLPr04691

Uniprot ID

ATRN_HUMAN

Uniprot Acc

O75882;A8KAE5;O60295;O95414;Q3MIT3;Q5TDA2;Q5TDA4;Q5VYW3;Q9NTQ3;Q9NTQ4;Q9NU01;Q9NZ57;Q9NZ58;Q9UC75;Q9UDF5;

Protein name

Attractin

Comment

FUNCTION:Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).||SUBUNIT:Monomer and homotrimer.||SUBCELLULAR LOCATION:Isoform 1:Cell membrane; Single-pass type I membrane protein.||SUBCELLULAR LOCATION:Isoform 2:Secreted.||SUBCELLULAR LOCATION:Isoform 3:Secreted.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Membrane; IsoId=O75882-1; Sequence=Displayed; Name=2; Synonyms=Secreted; IsoId=O75882-2; Sequence=VSP 001375; Name=3; IsoId=O75882-3; Sequence=VSP 001372, VSP 001375; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T lymphoc

Subcellular localization

Isoform 1:Cell membrane;Single-pass type I membrane protein.

Gene name

attractin

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MVAAAAATEARLRRRTAATAALAGRSGGPHWDWDVTRAGR PGLGAGLRLPRLLSPPLRPRLLLLLLLLSPPLLLLLLPC EAEAAAAAAAVSGSAAAEAKECDRPCVNGGRCNPGTGQC VCPAGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTK CTWLIEGQPNRIMRLRFNHFATECSWDHLYVYDGDSIYA PLVAAFSGLIVPERDGNETVPEVVATSGYALLHFFSDAA YNLTGFNITYSFDMCPNNCSGRGECKISNSSDTVECECS ENWKGEACDIPHCTDNCGFPHRGICNSSDVRGCSCFSDW QGPGCSVPVPANQSFWTREEYSNLKLPRASHKAVVNGNI MWVVGGYMFNHSDYNMVLAYDLASREWLPLNRSVNNVVV RYGHSLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNES WVLLTPKAKEQYAVVGHSAHIVTLKNGRVVMLVIFGHCP LYGYISNVQEYDLDKNTWSILHTQGALVQGGYGHSSVYD HRTRALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTIL KDSRFFRYLHTAVIVSGTMLVFGGNTHNDTSMSHGAKCF SSDFMAYDIACDRWSVLPRPDLHHDVNRFGHSAVLHNST MYVFGGFNSLLLSDILVFTSEQCDAHRSEAACLAAGPGI RCVWNTGSSQCISWALATDEQEEKLKSECFSKRTLDHDR CDQHTDCYSCTANTNDCHWCNDHCVPRNHSCSEGQISIF RYENCPKDNPMYYCNKKTSCRSCALDQNCQWEPRNQECI ALPENICGIGWHLVGNSCLKITTAKENYDNAKLFCRNHN ALLASLTTQKKVEFVLKQLRIMQSSQSMSKLTLTPWVGL RKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSE PSTRGLKAATCINPLNGSVCERPANHSAKQCRTPCALRT ACGDCTSGSSECMWCSNMKQCVDSNAYVASFPFGQCMEW YTMSTCPPENCSGYCTCSHCLEQP

Database cross reference

RefSeq Protein accession:NP_647537
RefSeq Protein gi:21450861

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005615;C:extracellular space;IDA:UniProtKB. GO:0005887;C:integral to plasma membrane;TAS:ProtInc.

GO-F

GO:0004872;F:receptor activity;TAS:ProtInc. GO:0005529;F:sugar binding;IEA:UniProtKB-KW.

GO-P

GO:0006954;P:inflammatory response;IEA:UniProtKB-KW.