Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr04735

Uniprot ID

AWAT1_HUMAN

Uniprot Acc

Q58HT5;Q5JT21;Q6IEE4;

Protein name

Acyl-CoA wax alcohol acyltransferase 1

Comment

FUNCTION:Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20).||CATALYTIC ACTIVITY:Acyl-CoA + a long-chain alcohol = CoA + a long-chain ester.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: Vmax=31.7 pmol/min/mg enzyme with [14C]oleoyl-CoA as substrate; Vmax=113 pmol/min/mg enzyme with [14C]cetyl-CoA as substrate;||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).||TISSUE SPECIFICITY:Predominantly expressed in skin, where it is limited to the sebaceous gland. Expressed in more mature, centrally located cells just before their rupture and sebum release. Also expressed in all tissues except spleen.

Subcellular localization

Endoplasmic reticulum membrane;Multi-pass membrane protein(By similarity).

Gene name

acyl-CoA wax alcohol acyltransferase 1

Protein sequence

MAHSKQPSHFQSLMLLQWPLSYLAIFWILQPLFVYLLFTS LWPLPVLYFAWLFLDWKTPERGGRRSAWVRNWCVWTHIR DYFPITILKTKDLSPEHNYLMGVHPHGLLTFGAFCNFCT EATGFSKTFPGITPHLATLSWFFKIPFVREYLMAKGVCS VSQPAINYLLSHGTGNLVGIVVGGVGEALQSVPNTTTLI LQKRKGFVRTALQHGAHLVPTFTFGETEVYDQVLFHKDS RMYKFQSCFRRIFGFYCCVFYGQSFCQGSTGLLPYSRPI VTVVGEPLPLPQIEKPSQEMVDKYHALYMDALHKLFDQH KTHYGCSETQKLFFL

Database cross reference

RefSeq Protein accession:NP_001013597
RefSeq Protein gi:61888902

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0047196;F:long-chain-alcohol O-fatty-acyltransferase activity;IEA:EC.

GO-P

GO:0008610;P:lipid biosynthetic process;IEA:UniProtKB-KW.

Pathway

Pathway name

Retinol_Metabolism