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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr04742

Uniprot ID

AXIN1_HUMAN

Uniprot Acc

O15169;Q4TT26;Q4TT27;Q86YA7;Q8WVW6;Q96S28;

Protein name

Axin-1

Comment

FUNCTION:Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.||SUBUNIT:Homodimer (By similarity). Component of the beta-catenin destruction complex, containing at least, CTNNB1, an axin and GSK3B, that regulates CTNNB1 protein leve

Subcellular localization

Cytoplasm.Nucleus.

Gene name

axin 1

Protein sequence

MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPA SYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPT PPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFW FACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVS RQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEEN TYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGIS GYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLE TAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALA PATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQH RREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEE LIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGDPSSG PPGPCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPES ILDEHVQRVLRTPGRQSPGPGHRSPDSGHVAKMPVALGG AASGHGKHVPKSGAKLDAAGLHHHRHVHHHVHHSTARPK EQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAP NASDGLAHSGKVGVACKRNAKKAESGKSASTEVPGASED AEKNQKIMQWIIEGEKEISRHRRTGHGSSGTRKPQPHEN SRPLSLEHPWAGPQLRTSVQPSHLFIQDPTMPPHPAPNP LTQLEEARRRLEEEEKRASRAPSKQRYVQEVMRRGRACV RPACAPVLHVVPAVSDMELSETETRSQRKVGGGSAQPCD SIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSY RYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD

Database cross reference

RefSeq Protein accession:NP_003493
RefSeq Protein gi:27501450

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0034742;C:APC-Axin-1-beta-catenin complex;IDA:BHF-UCL. GO:0034747;C:Axin-APC-beta-catenin-GSK3B complex;IDA:BHF-UCL. GO:0030877;C:beta-catenin destruction complex;IDA:UniProtKB. GO:0005938;C:cell cortex;ISS:RefGenome. GO:0016023;C:cytoplasmic membra

GO-F

GO:0070016;F:armadillo repeat domain binding;ISS:BHF-UCL. GO:0008013;F:beta-catenin binding;IDA:BHF-UCL. GO:0005096;F:GTPase activator activity;ISS:RefGenome. GO:0070411;F:I-SMAD binding;IPI:BHF-UCL. GO:0002039;F:p53 binding;IDA:MGI. GO:0032947;F:prot

GO-P

GO:0007257;P:activation of JUN kinase activity;ISS:RefGenome. GO:0032147;P:activation of protein kinase activity;IDA:BHF-UCL. GO:0006915;P:apoptosis;IEA:UniProtKB-KW. GO:0048320;P:axial mesoderm formation;ISS:RefGenome. GO:0060823;P:canonical Wnt recep

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr04742

PHOSPHORYLATION

213

T

Phospho-ELM

31697

HTP

N

HuLPr04742

PHOSPHORYLATION

217

S

Phospho-ELM

31696

HTP

N

HuLPr04742

PHOSPHORYLATION

77

S

Phospho-ELM

31695

HTP

N

HuLPr04742

PHOSPHORYLATION

787

Y

PhosphoSitePlus

463032

LTP

N

HuLPr04742

PHOSPHORYLATION

788

Y

PhosphoSitePlus

463033

LTP

N

HuLPr04742

PHOSPHORYLATION

796

Y

PhosphoSitePlus

463034

LTP

N

HuLPr04742

PHOSPHORYLATION

148

Y

PhosphoSitePlus

3072147

LTP

N

HuLPr04742

PHOSPHORYLATION

160

T

PhosphoSitePlus

3072727

LTP

N

HuLPr04742

PHOSPHORYLATION

217

S

PhosphoSitePlus

3174923

LTP

N

HuLPr04742

PHOSPHORYLATION

77

S

PhosphoSitePlus

3174926

HTP

N

HuLPr04742

PHOSPHORYLATION

79

T

PhosphoSitePlus

471497

LTP

N

HuLPr04742

PHOSPHORYLATION

75

S

PhosphoSitePlus

4697306

LTP

N

Pathway

Pathway name

Degradation_of_beta_catenin

Pathway name

C-MYC_pathway

Pathway name

N-cadherin_signaling_events

Pathway name

Presenilin_action_in_Notch_and_Wnt_signaling

Pathway name

TGF-beta_receptor_signaling

Pathway name

Canonical_Wnt_signaling_pathway

Pathway name

EGF/MAPK

Pathway name

TGF-

Pathway name

WNT/Wingless