Protein basic information
| LiverAtlas Protein ID |
HuLPr04743 |
|
Uniprot ID |
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Uniprot Acc |
Q9Y2T1;Q3MJ88;Q9H3M6;Q9UH84; |
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Protein name |
Axin-2 |
|
Comment |
FUNCTION:Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity).||SUBUNIT:Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and RNF111. Interacts with ANKRD6.||SUBCELLULAR LOCATION:Cytoplasm.||TISSUE SPECIFICITY:Expressed in brain and lymphoblast.||DOMAIN:The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2 (By similarity).||PTM:Probably phosphorylated by GSK3B and dephosphorylated by PP2A (By similarity).||PTM:ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP- ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.||PTM:Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation |
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Subcellular localization |
Cytoplasm. |
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Gene name |
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Protein sequence
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MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGV GKGQVTKPMSVSSNTRRNEDGLGEPEGRASPDSPLTRWT KSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFR QMNLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYI RDGIKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTSDIY LEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWT CADFKCKLSPTVVGLSSKTLRATASVRSTETVDSGYRSF KRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMS MTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHF PRTHRLPKEMTPVEPATFAAELISRLEKLKLELESRHSL EERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGS YEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDH HHHHHSQYHSLLPPGGKLPPAAASPGACPLLGGKGFVTK QTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGS EYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGT EPGLALPAREGGAPGGAGALQLPREEGDRSQDVWQWMLE SERQSKPKPHSAQSTKKAYPLESARSSPGERASRHHLWG GNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRR LAEVSKPPKQRCCVASQQRDRNHSATVQTGATPFSNPSL APEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRML KAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEE IWEDETVLPMYEGRILGKVERID |
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Database cross reference |
RefSeq Protein accession:NP_004646
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0034747;C:Axin-APC-beta-catenin-GSK3B complex;NAS:BHF-UCL. GO:0005938;C:cell cortex;ISS:RefGenome. GO:0005813;C:centrosome;IDA:BHF-UCL. GO:0016023;C:cytoplasmic membrane-bounded vesicle;ISS:RefGenome. GO:0005881;C:cytoplasmic microtubule;ISS:RefGeno |
|
GO-F |
GO:0070016;F:armadillo repeat domain binding;ISS:RefGenome. GO:0008013;F:beta-catenin binding;NAS:BHF-UCL. GO:0005096;F:GTPase activator activity;ISS:RefGenome. GO:0019901;F:protein kinase binding;ISS:RefGenome. GO:0004871;F:signal transducer activity; |
|
GO-P |
GO:0034613;P:cellular protein localization;IDA:BHF-UCL. GO:0071407;P:cellular response to organic cyclic compound;ISS:RefGenome. GO:0009950;P:dorsal/ventral axis specification;ISS:RefGenome. GO:0001957;P:intramembranous ossification;ISS:RefGenome. GO:0 |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr04743 |
ACETYLATION |
792 |
K |
PhosphoSitePlus |
HTP |
N |
 
|
|
|
HuLPr04743 |
ACETYLATION |
797 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04743 |
ACETYLATION |
806 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr04743 |
PHOSPHORYLATION |
549 |
Y |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name | |
| Pathway name | |
| Pathway name | |
| Pathway name |
