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Protein basic information

LiverAtlas Protein ID

HuLPr08286

Uniprot ID

B4DEX8_HUMAN

Uniprot Acc

B4DEX8;

Protein name

S-adenosylmethionine synthase

Comment

FUNCTION:Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity).||CATALYTIC ACTIVITY:ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.||COFACTOR:Binds 1 potassium ion per subunit (By similarity).||COFACTOR:Binds 2 divalent ions per subunit. Magnesium or cobalt (By similarity).||PATHWAY:Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine:step 1/1.||SIMILARITY:Belongs to the AdoMet synthase family.

Gene name

methionine adenosyltransferase II, alpha

Protein sequence

MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDA VLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDY QKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIA QGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLA HKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVL PIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKY LDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGW GAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRR VLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKN FDLRPGVIVR

Database cross reference

RefSeq Protein accession:NP_005902
RefSeq Protein gi:5174529

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0004478;F:methionine adenosyltransferase activity;IEA:EC.

GO-P

GO:0006730;P:one-carbon metabolic process;IEA:UniProtKB-KW.