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Protein basic information

LiverAtlas Protein ID

HuLPr08430

Uniprot ID

B4DGD0_HUMAN

Uniprot Acc

B4DGD0;

Protein name

cDNA FLJ50491, highly similar to Amyloid beta A4 protein (APP) (ABPP)(Alzheimer disease amyloid protein) (Cerebral vascularamylo

Comment

SIMILARITY:Contains 1 BPTI/Kunitz inhibitor domain.

Gene name

amyloid beta (A4) precursor protein

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQN WCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKF LHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPC GIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGA DTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGD EVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVC SEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNN FDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAA STPDAVDKYLETPGDESEHAHFQKAKERLEAKHRERMSQ VMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAA NERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPR PRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQ IRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDE LLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTT VELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDA RPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGY EVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN

Database cross reference

RefSeq Protein accession:NP_000475
RefSeq Protein gi:4502167

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005794;C:Golgi apparatus;IDA:HPA. GO:0016021;C:integral to membrane;IEA:InterPro.

GO-F

GO:0005488;F:binding;IEA:InterPro. GO:0008233;F:peptidase activity;IEA:UniProtKB-KW. GO:0004867;F:serine-type endopeptidase inhibitor activity;IEA:InterPro.

Pathway

Pathway name

IL2