HuLPr10490

Uniprot ID

B4E0X6_HUMAN

Uniprot Acc

B4E0X6;

Protein name

Proteasome subunit alpha type

Comment

FUNCTION:The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).||CATALYTIC ACTIVITY:Cleavage of peptide bonds with very broad specificity.||SUBUNIT:The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits (By similarity).||SUBCELLULAR LOCATION:Cytoplasm. Nucleus (By similarity).||SIMILARITY:Belongs to the peptidase T1A family.

Subcellular localization

Cytoplasm.Nucleus(By similarity).

Gene name

proteasome (prosome, macropain) subunit, alpha type, 1

Protein sequence

MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKS KTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTA DARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSSILF MLAFMDMNFEGF

Database cross reference

RefSeq Protein accession:NP_001137409
RefSeq Protein gi:221316716

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. GO:0019773;C:proteasome core complex, alpha-subunit complex;IEA:InterPro.

GO-F

GO:0004298;F:threonine-type endopeptidase activity;IEA:UniProtKB-KW.

GO-P

GO:0006511;P:ubiquitin-dependent protein catabolic process;IEA:InterPro.