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Protein basic information

LiverAtlas Protein ID

HuLPr10973

Uniprot ID

B5BU61_HUMAN

Uniprot Acc

B5BU61;

Protein name

Histone deacetylase

Comment

CATALYTIC ACTIVITY:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.||SUBCELLULAR LOCATION:Nucleus (By similarity).||SIMILARITY:Belongs to the histone deacetylase family. HD Type 1 subfamily.

Subcellular localization

Nucleus(By similarity).

Gene name

histone deacetylase 1

Protein sequence

MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHN LLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSI RPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSV ASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIV LAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTV SFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDE SYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCF NLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWT YETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTS QNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPE ESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGG RKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEK PEAKGVKEEVKLA

Database cross reference

RefSeq Protein accession:NP_004955
RefSeq Protein gi:13128860

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

Ontology annotation

GO-C

GO:0005634;C:nucleus;IDA:HPA.

GO-F

GO:0034739;F:histone deacetylase activity (H3-K16 specific);IEA:EC. GO:0032041;F:NAD-dependent histone deacetylase activity (H3-K14 specific);IEA:EC. GO:0046969;F:NAD-dependent histone deacetylase activity (H3-K9 specific);IEA:EC. GO:0046970;F:NAD-depen

GO-P

GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW.