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Protein basic information

LiverAtlas Protein ID

HuLPr11011

Uniprot ID

B5LY64_HUMAN

Uniprot Acc

B5LY64;

Protein name

Orotidine 5'-phosphate decarboxylase

Comment

CATALYTIC ACTIVITY:Orotidine 5'-phosphate = UMP + CO(2).||PATHWAY:Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate:step 2/2.||SIMILARITY:Belongs to the OMP decarboxylase family.

Gene name

uridine monophosphate synthetase

Protein sequence

MLEILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSI KEAPKELSFGARAELPRIHPVASKLLRLMQKKETNLCLS ADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMK ELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIAS WADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSST GSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFL HLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRG IISAADRLEAAEMYRKAAWEAYLSRLGV

Database cross reference

RefSeq Protein accession:NP_000364
RefSeq Protein gi:4507835

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

Ontology annotation

GO-F

GO:0004590;F:orotidine-5'-phosphate decarboxylase activity;IEA:EC. GO:0016740;F:transferase activity;IEA:UniProtKB-KW.

GO-P

GO:0006207;P:'de novo' pyrimidine base biosynthetic process;IEA:InterPro. GO:0044205;P:'de novo' UMP biosynthetic process;IEA:InterPro.