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Protein basic information

LiverAtlas Protein ID

HuLPr11143

Uniprot ID

B6D4Y3_HUMAN

Uniprot Acc

B6D4Y3;

Protein name

Tyrosine-protein kinase receptor

Comment

CATALYTIC ACTIVITY:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.||SIMILARITY:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.||SIMILARITY:Contains 1 protein kinase domain.

Gene name

anaplastic lymphoma receptor tyrosine kinase

Protein sequence

MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQP REPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSE LKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPA EARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGP PGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKAS EVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPS PSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCEL EYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSK EMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVH RHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQG RIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTS PGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQ MCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKD ARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSP CELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAA YEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAF DNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKEL KPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNN AYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAA GGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGED ACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGG GGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPE RLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQE GATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGY IGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGH GEVNIKHYLNCSHCEVDECHMDPE

Database cross reference

RefSeq Protein accession:NP_004295
RefSeq Protein gi:29029632

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0004714;F:transmembrane receptor protein tyrosine kinase activity;IEA:EC.

GO-P

GO:0007169;P:transmembrane receptor protein tyrosine kinase signaling pathway;IEA:InterPro.