HuLPr11237

Uniprot ID

B7U6Z8_HUMAN

Uniprot Acc

B7U6Z8;

Protein name

NADH-ubiquinone oxidoreductase chain 5

Comment

FUNCTION:Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).||CATALYTIC ACTIVITY:NADH + ubiquinone = NAD(+) + ubiquinol.||SUBCELLULAR LOCATION:Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).||SIMILARITY:Belongs to the complex I subunit 5 family.

Subcellular localization

Mitochondrion inner membrane;Multi-pass membrane protein(By similarity).

Gene name

NADH dehydrogenase, subunit 5 (complex I)

Protein sequence

MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIV ASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLS FKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFF KYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISW WYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSW DPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPS AMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQ TLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLM MVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNN EQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYS KDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLT LTGQPRFPTLTNINENNPTLLNPIKRLTAGSLFAGFLIT NNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLT NKLKMKSPLYTFYFSNMLGFYPSITHRTIPYLGLLASQN LPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKL YFLSFFFPLILTLLLIT

Database cross reference

RefSeq Protein accession:YP_003024036
RefSeq Protein gi:251831117

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005743;C:mitochondrial inner membrane;IEA:UniProtKB-SubCell. GO:0070469;C:respiratory chain;IEA:UniProtKB-KW.

GO-F

GO:0008137;F:NADH dehydrogenase (ubiquinone) activity;IEA:InterPro.

GO-P

GO:0042773;P:ATP synthesis coupled electron transport;IEA:InterPro. GO:0006810;P:transport;IEA:UniProtKB-KW.