HuLPr12884

Uniprot ID

BCAM_HUMAN

Uniprot Acc

P50895;A8MYF9;A9YWT5;A9YWT6;Q86VC7;

Protein name

Basal cell adhesion molecule

Comment

FUNCTION:Laminin alpha-5 receptor. May mediate intracellular signaling.||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||TISSUE SPECIFICITY:Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.||DEVELOPMENTAL STAGE:Is under developmental control in liver and may also be regulated during differentiation in other tissues. Up- regulated following malignant transformation in some cell types.||PTM:Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin.||POLYMORPHISM:BCAM is responsible for the Lutheran blood group system (LU) [MIM:111200]. Lutheran is a complex blood group system consisting of 19 antigens. Antigens Lu(a) and Lu(b) are defined by a polymorphism at position 77:Lu(a) has His-77 and Lu(b) has Arg- 77.||POLYMORPHISM:Inactivating variants in BCAM are responsible for the recessive Lutheran N phenotype Lu(a-

Subcellular localization

Membrane;Single-pass type I membrane protein.

Gene name

basal cell adhesion molecule (Lutheran blood group)

Protein sequence

MEPPDAPAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPL VEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLA SAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVG DERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPV EMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASF HCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSP STPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEV LNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSK TLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPT PALRWTKDSTPLGDGPMLSLSSITFDSNGTYVCEASLPT VPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEV TLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLT LKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQA GVAVMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKG APPPGEPGLSHSGSEQPEQTGLLMGGASGGARGGSGGFGDEC

Database cross reference

RefSeq Protein accession:NP_001013275
RefSeq Protein gi:61742797

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0009897;C:external side of plasma membrane;IC:BHF-UCL. GO:0005887;C:integral to plasma membrane;TAS:ProtInc.

GO-F

GO:0043236;F:laminin binding;IMP:BHF-UCL. GO:0005055;F:laminin receptor activity;IMP:BHF-UCL.

GO-P

GO:0007160;P:cell-matrix adhesion;IMP:BHF-UCL.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr12884

PHOSPHORYLATION

598

S

PhosphoSitePlus

1713901

HTP

N

HuLPr12884

PHOSPHORYLATION

596

S

PhosphoSitePlus

1713902

LTP

HTP

N

HuLPr12884

PHOSPHORYLATION

621

S

PhosphoSitePlus

455912

LTP

N