HuLPr12933

Uniprot ID

BEX1_HUMAN

Uniprot Acc

Q9HBH7;A0AVN1;A8K4J3;Q9NZ33;

Protein name

Protein BEX1

Comment

FUNCTION:Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).||SUBUNIT:Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP (By similarity).||SUBCELLULAR LOCATION:Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus (By similarity).||TISSUE SPECIFICITY:Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia.||PTM:Phosphorylated. Phosphorylation of Ser-102 protects i

Subcellular localization

Nucleus.Cytoplasm.

Gene name

brain expressed, X-linked 1

Protein sequence

MESKEKRAVNSLSMENANQENEEKEQVANKGEPLALPLDA GEYCVPRGNRRRFRVRQPILQYRWDMMHRLGEPQARMRE ENMERIGEEVRQLMEKLREKQLSHSLRAVSTDPPHHDHH DEFCLMP

Database cross reference

RefSeq Protein accession:NP_060946
RefSeq Protein gi:68533249

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-P

GO:0030154;P:cell differentiation;IEA:UniProtKB-KW. GO:0007399;P:nervous system development;IEA:UniProtKB-KW.

p75(NTR)-mediated_signaling