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Protein basic information

LiverAtlas Protein ID

HuLPr13005

Uniprot ID

BMP8A_HUMAN

Uniprot Acc

Q7Z5Y6;Q5T3A5;

Protein name

Bone morphogenetic protein 8A

Comment

FUNCTION:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).||SUBUNIT:Homodimer; disulfide-linked (By similarity).||SUBCELLULAR LOCATION:Secreted.||SIMILARITY:Belongs to the TGF-beta family.||WEB RESOURCE:Name=Wikipedia; Note=Bone morphogenetic protein 8A entry; URL="http://en.wikipedia.org/wiki/Bone morphogenetic protein 8A";

Subcellular localization

Secreted.

Gene name

bone morphogenetic protein 8a

Protein sequence

MAARPGPLWLLGLTLCALGGGGPGLRPPPGCPQRRLGARE RRDVQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLD LYHAMAGDDDEDGAPAEQRLGRADLVMSFVNMVERDRAL GHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLL NRTLHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLV LDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGL LGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPK KSNELPQANRLPGIFDDVRGSHGRQVCRRHELYVSFQDL GWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQS LVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKH RNMVVKACGCH

Database cross reference

RefSeq Protein accession:NP_861525
RefSeq Protein gi:145611428

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005615;C:extracellular space;IEA:UniProtKB-KW.

GO-F

GO:0005125;F:cytokine activity;IEA:UniProtKB-KW. GO:0008083;F:growth factor activity;IEA:UniProtKB-KW.

GO-P

GO:0051216;P:cartilage development;IEA:UniProtKB-KW. GO:0030154;P:cell differentiation;IEA:UniProtKB-KW. GO:0040007;P:growth;IEA:InterPro. GO:0001503;P:ossification;IEA:UniProtKB-KW.