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Protein basic information

LiverAtlas Protein ID

HuLPr13007

Uniprot ID

BMPER_HUMAN

Uniprot Acc

Q8N8U9;A8K1P8;Q8TF36;

Protein name

BMP-binding endothelial regulator protein

Comment

FUNCTION:Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.||SUBUNIT:Interacts with BMP4 (By similarity).||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Highly expressed in lung, and brain and also in primary chondrocytes.||SIMILARITY:Contains 1 TIL (trypsin inhibitory-like) domain.||SIMILARITY:Contains 5 VWFC domains.||SIMILARITY:Contains 1 VWFD domain.

Subcellular localization

Secreted.

Gene name

BMP binding endothelial regulator

Protein sequence

MLWFSGVGALAERYCRRSPGITCCVLLLLNCSGVPMSLAS SFLTGSVAKCENEGEVLQIPFITDNPCIMCVCLNKEVTC KREKCPVLSRDCALAIKQRGACCEQCKGCTYEGNTYNSS FKWQSPAEPCVLRQCQEGVVTESGVRCVVHCKNPLEHLG MCCPTCPGCVFEGVQYQEGEEFQPEGSKCTKCSCTGGRT QCVREVCPILSCPQHLSHIPPGQCCPKCLGQRKVFDLPF GSCLFRSDVYDNGSSFLYDNCTACTCRDSTVVCKRKCSH PGGCDQGQEGCCEECLLRVPPEDIKVCKFGNKIFQDGEM WSSINCTICACVKGRTECRNKQCIPISSCPQGKILNRKG CCPICTEKPGVCTVFGDPHYNTFDGRTFNFQGTCQYVLT KDCSSPASPFQVLVKNDARRTRSFSWTKSVELVLGESRV SLQQHLTVRWNGSRIALPCRAPHFHIDLDGYLLKVTTKA GLEISWDGDSFVEVMAAPHLKGKLCGLCGNYNGHKRDDL IGGDGNFKFDVDDFAESWRVESNEFCNRPQRKPVPELCQ GTVKVKLRAHRECQKLKSWEFQTCHSTVDYATFYRSCVT DMCECPVHKNCYCESFLAYTRACQREGIKVHWEPQQNCA ATQCKHGAVYDTCGPGCIKTCDNWNEIGPCNKPCVAGCH CPANLVLHKGRCIKPVLCPQR

Database cross reference

RefSeq Protein accession:NP_597725
RefSeq Protein gi:37693519

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005615;C:extracellular space;IDA:BHF-UCL.

GO-P

GO:0002043;P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis;IDA:BHF-UCL. GO:0042118;P:endothelial cell activation;IDA:BHF-UCL. GO:0030514;P:negative regulation of BMP signaling pathway;TAS:BHF-UCL. GO:0070374;P:positive r