HuLPr13036

Uniprot ID

BPHL_HUMAN

Uniprot Acc

Q86WA6;Q00306;Q13855;Q3KP51;

Protein name

Valacyclovir hydrolase

Comment

FUNCTION:Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.||SUBUNIT:Monomer. May also form homodimers.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Beta; IsoId=Q86WA6-1; Sequence=Displayed; Name=2; Synonyms=Alpha; IsoId=Q86WA6-2; Sequence=VSP 009115;||TISSUE SPECIFICITY:Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle.||SIMILARITY:Belongs to the AB hydrolase superfamily. Lipase family.

Gene name

biphenyl hydrolase-like (serine hydrolase)

Protein sequence

MVAVLGGRGVLRLRLLLSALKPGIHVPRAGPAAAFGTSVT SAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETDFGP QLKNLNKKLFTVVAWDPRGYGHSRPPDRDFPADFFERDA KDAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIH KMVIWGANAYVTDEDSMIYEGIRDVSKWSERTRKPLEAL YGYDYFARTCEKWVDGIRQFKHLPDGNICRHLLPRVQCP ALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNL HLRFADEFNKLAEDFLQ

Database cross reference

RefSeq Protein accession:NP_004323
RefSeq Protein gi:221316588

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005739;C:mitochondrion;ISS:UniProtKB.

GO-F

GO:0016787;F:hydrolase activity;IEA:UniProtKB-KW.

GO-P

GO:0006520;P:cellular amino acid metabolic process;TAS:ProtInc. GO:0009636;P:response to toxin;TAS:ProtInc.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr13036

ACETYLATION

257

K

PhosphoSitePlus

11324934

HTP

N

HuLPr13036

ACETYLATION

126

K

PhosphoSitePlus

479597

LTP

N